Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa
Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa
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DOI：
10.1160/th03-12-0732
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发表时间：
2004-08-01
影响因子：
6.7
通讯作者：
Schmidtchen, A
中科院分区：
文献类型：
--
作者：
Lundqvist, K;Herwald, H;Schmidtchen, A
最近，Gautam等人证明了这一点。中性粒细胞携带的肝素结合蛋白(HBP)的释放，也称为CAP37/天青素，诱导内皮细胞高通透性和中性粒细胞外流。在这里，我们显示慢性小腿溃疡液，与急性创面的创面液相比，含有高度升高的HBR免疫组织化学显示，慢性溃疡组织中存在HBP。此外，还发现了铜绿假单胞菌的分泌产物，可以诱导人中性粒细胞释放HBP。我们的数据表明细菌的存在和慢性溃疡中HBP的释放之间可能存在联系。因此，靶向HBP为减少慢性溃疡的内皮屏障功能障碍提供了一个有趣的选择。
Recently it was demonstrated by Gautam, et al. that release of neutrophil-borne heparin-binding protein (HBP), also known as CAP37/azurocidin, induced endothelial hyperpermeability and neutrophil efflux. Here, we show that chronic leg ulcer fluid, in contrast to wound fluid from acute wounds, contains highly increased levels of HBR Immunohistochemistry demonstrated the presence of HBP in chronic ulcer tissues. Furthermore, secreted products of Pseudomonas aeruginoso were found, to induce release of HBP from human neutrophils. Our data suggest a possible link between bacterial presence and HBP-release in chronic ulcers. Thus, targeting HBP offers an interesting option for reduction of endothelial barrier dysfunction in chronic ulcers.