Skeletal muscle regeneration in very old rats
Skeletal muscle regeneration in very old rats
复制标题
DOI：
10.1093/gerona/56.5.b224
复制
发表时间：
2001-05-01
影响因子：
5.1
通讯作者：
Faulkner, JA
中科院分区：
文献类型：
--
作者：
Carlson, BM;Dedkov, EI;Faulkner, JA
本研究旨在评估接近正常寿命末期的大鼠骨骼肌的再生能力。进行了两个实验。首先，将32月龄雄性近交系Wister （WI/HicksCar）大鼠的指长伸肌（EDL）移植到4月龄宿主的指长伸肌中。另一块EDL肌为自体移植。60天后，衰老变年轻的肌肉移植和年轻变年轻的自体移植都能再生。在第二组实验中，给WI/HicksCar和Brown Norway （BN）的年轻成年大鼠（4个月）和老年大鼠（32和34个月）注射局麻药布比卡因，让EDL肌肉再生41天。在所有情况下，再生肌的质量和绝对最大强直力等于或超过未接触的对侧对照肌。这些实验表明，在适当的条件下，非常老的肌肉可以再生到等于或超过对侧控制值，而老年大鼠的肌肉再生能力远低于年轻大鼠。
This study was undertaken to assess the regenerative capacity of skeletal muscle in rats near the end of their normal life span. Two experiments were performed. In the first, extensor digitorum longus (EDL) muscles were cross-age transplanted from 32-month-old male inbred Wister (WI/HicksCar) rats in place of an EDL muscle in 4-month-old hosts. The other EDL muscle in the hosts was autotransplanted. After 60 days, the old-into-young muscle transplants regenerated as well as the young-into-young autotransplants. In the second experiment, EDL muscles in young adult (4 months) and old rats (32 and 34 months) of WI/HicksCar and Brown Norway (BN) were injected with a local anesthetic, bupivacaine, and allowed to regenerate for 41 days. In all cases, the masses and absolute maximum tetanic force of the regenerates equaled or exceeded those of untouched contralateral control muscles. These experiments showed that under appropriate conditions, very old muscles can regenerate to equal or exceed the contralateral control values, which in old rats are much less than those in muscles of young rats.