The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells.
The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells.
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DOI：
10.1021/jm00008a020
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发表时间：
1995-04
影响因子：
7.3
通讯作者：
John C. Stowell;Rachel I. Huot;Lainie Van Voast
中科院分区：
文献类型：
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作者：
John C. Stowell;Rachel I. Huot;Lainie Van Voast
我们开发了一种以辛二酸甲酯为原料合成 N-羟基-N'-苯基辛二酰胺的实用方法。它通过简单的纯化过程提供高产率和纯度的产品。我们发现在10(-5) M 时它对体外T/5 AXC/SSh 大鼠前列腺癌细胞具有显着的作用。它是细胞增殖的有效抑制剂，可以改变细胞形态以类似于非恶性细胞。
We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid. It provides the product in high yield and purity with a simple purification process. We have found that at 10(-5) M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro. It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.