Enterotoxigenic Escherichia coli heat-labile toxin seroconversion in US travelers to Mexico.
Enterotoxigenic Escherichia coli heat-labile toxin seroconversion in US travelers to Mexico.
复制标题
前往墨西哥的美国旅行者中产肠毒素大肠杆菌不耐热毒素血清转化。
DOI：
10.1111/j.1708-8305.2008.00187.x
复制
发表时间：
2008
影响因子：
25.7
通讯作者：
Okhuysen,PabloC
中科院分区：
文献类型：
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作者：
Flores,Jose;DuPont,HerbertL;Jiang,Zhi-Dong;Belkind-Gerson,Jaime;Mohamed,JamalA;Carlin,LilyG;Padda,RanjitS;Paredes,Mercedes;Martinez-Sandoval,JoseFrancisco;Villa,NicolasA;Okhuysen,PabloC
Background and AimsEnterotoxigenicEscherichia coli(ETEC) is the most common bacterial pathogen isolated from travelers suffering of diarrhea. Exposure to heat‐labile toxin (LT) produces a high rate of seroconversion. However, the role of LT‐producing ETEC (LT‐ETEC) as a cause of diarrhea is controversial. We conducted a cohort study in US students traveling to Mexico to assess the ETEC‐LT seroconversion rate after natural exposure.MethodsParticipants provided a serum sample on arrival and departure and a stool sample when ill. ETEC‐LT immunoglobulin G antibodies were measured by enzyme‐linked immunosorbent assay, and LT‐ETEC were detected by means of polymerase chain reaction done on fecal DNA.ResultsA total of 422 participants with a mean age of 34.5 years were followed a mean of 19.9 days; 304 were females (72.0%), and 319 (75.6%) traveled during the summer months. In total, 177 individuals (41.9%) developed travelers’ diarrhea and 33.9% had LT‐ETEC identified in their stools. Among individuals having an LT‐ETEC strain, 74% seroconverted compared to 11% of those not having diarrhea (p< 0.0001). When analyzed with a logistic regression model, the odds of seroconversion were significantly reduced in participants not having LT‐ETEC in their stool (odds ratio = 0.1,p< 0.0001) after adjusting for season, length of stay, age, gender, race, and ethnicity.ConclusionIn US young adults traveling to Mexico, ETEC‐LT seroconversion reliably identifies individuals naturally exposed to ETEC and correlates with symptomatic illness, length and season of travel.
