Influence of hydrocortisone acetate administered to the lactating rat on protein and lactose content in milk and serum protein, glucose and insulin levels in dams and pups.
Influence of hydrocortisone acetate administered to the lactating rat on protein and lactose content in milk and serum protein, glucose and insulin levels in dams and pups.
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DOI：
10.1055/s-2007-1004854
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发表时间：
1990-02
期刊：
影响因子：
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通讯作者：
J. Llopis;A. Lampreabe;M. López Frías;F. Perán;N. Blanco Martínez;G. Urbano;M. Montellano
中科院分区：
文献类型：
--
作者：
J. Llopis;A. Lampreabe;M. López Frías;F. Perán;N. Blanco Martínez;G. Urbano;M. Montellano
I. M的影响。研究了在哺乳期的前15天期间对母亲施用醋酸氢化可的松（剂量为0.4、0.8或2.0mg/100 g体重/天）对母鼠和幼鼠的乳蛋白和乳糖组成以及血清蛋白、葡萄糖和胰岛素水平的影响。母鼠的总血清蛋白和白蛋白/球蛋白比在给药期间未发生变化。每日注射0.4或0.8 mg/100 g体重不能改变母鼠的血清葡萄糖或胰岛素水平，而2.0 mg/100 g体重的剂量导致血糖升高（从118 +/- 3.2到133 +/- 5.3），伴随着胰岛素血症的急剧变化（从40.7 +/- 4.1到83.6 +/- 6.9）。所有三种剂量都提高了牛奶中的蛋白质水平。在2.0 mg/100 g体重时记录到最小的增加;该剂量也降低了牛奶乳糖含量。幼仔的血清总蛋白略有升高，但不显著，对白蛋白/球蛋白比或血糖和胰岛素水平无显著影响。
The influence of i.m. administration to the mother of hydrocortisone acetate (doses of 0.4, 0.8 or 2.0 mg/100 g body weight/day) during the first 15 days of lactation on milk protein and lactose composition and serum levels of protein, glucose and insulin in dams and pups is studied. Total serum proteins and albumin/globulin ratio in dams were unchanged by treatment. The daily injection of 0.4 or 0.8 mg/100 g body weight failed to alter serum levels of glucose or insulin in dams, whereas a dose of 2.0 mg/100 g body weight led to a rise in glucemia (from 118 +/- 3.2 to 133 +/- 5.3) which was accompanied by a sharp change in insulinemia (from 40.7 +/- 4.1 to 83.6 +/- 6.9). All three doses raised protein levels in milk. The smallest increase was recorded with 2.0 mg/100 g body weight; this dose also reduced milk lactose content. Total serum proteins in pups rose slightly but nonsignificantly, and no significant effects were noted on albumin/globulin ratio or serum glucose and insulin levels.