Bob Goldstein: cell biology by way of development. Interviewed by Caitlin Sedwick.
Bob Goldstein: cell biology by way of development. Interviewed by Caitlin Sedwick.
复制标题
鲍勃·戈德斯坦（Bob Goldstein）：细胞生物学的发展之路。
DOI：
10.1083/jcb.2023pi
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Goldstein,Bob
中科院分区：
文献类型：
--
作者：
Goldstein,Bob
细胞间的相互作用、不对称的细胞分裂和细胞运动为复杂体型的发育奠定了基础。但这些现象背后的细胞过程仍在研究中。在他的整个职业生涯中，鲍勃·戈尔茨坦一直致力于用C.优雅他的早期工作，展示了细胞-细胞相互作用如何驱动蠕虫内胚层和有丝分裂纺锤体方向的规范（1，2）以及精子进入点如何决定新胚胎的发育轴（3），已成为该领域经典的一部分。从那时起，戈尔茨坦的兴趣继续沿着沿着新的轴线发展（4-5），正如我们在查佩尔山的北卡罗来纳州大学实验室与我们交谈时所听到的那样。
Cell–cell interactions, asymmetric cell divisions, and cell movements set the foundation for the development of complex body forms. But the cellular processes underlying these phenomena are still being investigated. Throughout his career, Bob Goldstein has worked to (literally) dissect the mechanisms of embryonic development using C. elegans. His early work, showing how cell–cell interactions drive specification of the worm endoderm and mitotic spindle orientation (1, 2) and how the point of sperm entry determines the developmental axis of the new embryo (3), has become part of the canon of the field. Since then, Goldstein’s interests have continued to develop along new axes (4–5), as we heard when he spoke with us from his lab at the University of North Carolina at Chapel Hill.