Saccadic dysmetria and adaptation after lesions of the cerebellar cortex
Saccadic dysmetria and adaptation after lesions of the cerebellar cortex
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DOI：
10.1523/jneurosci.19-24-10931.1999
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发表时间：
1999-12-15
影响因子：
5.3
通讯作者：
Thier, P
中科院分区：
文献类型：
--
作者：
Barash, S;Melikyan, A;Thier, P
我们研究了小脑皮质眼蚓部的小病变对猴子执行和适应扫视眼球运动能力的影响。对于一个水平方向的扫视，病变导致最初的总屈光不正和快速适应能力的永久性废除。平均眼跳幅度从初始的屈光不正恢复，但变异性仍然很高。在同一方向上的一系列数百次重复扫视导致幅度逐渐减小。其他方向的扫视受病变的影响较小。我们建议如下。(1)小脑皮层不断地重新校准扫视系统，从而补偿可能由肌肉疲劳引起的快速生物力学变化。(2)尽管永久缺乏快速适应，但发现了一种从辨距障碍中缓慢恢复的机制。
We studied the effects of small lesions of the oculomotor vermis of the cerebellar cortex on the ability of monkeys to execute and adapt saccadic eye movements. For saccades in one horizontal direction, the lesions led to an initial gross hypometria and a permanent abolition of the capacity for rapid adaptation. Mean saccade amplitude recovered from the initial hypometria, although variability remained high. A series of hundreds of repetitive saccades in the same direction resulted in gradual decrement of amplitude. Saccades in other directions were less strongly affected by the lesions. We suggest the following. (1) The cerebellar cortex is constantly recalibrating the saccadic system, thus compensating for rapid biomechanical changes such as might be caused by muscle fatigue. (2) A mechanism capable of slow recovery from dysmetria is revealed despite the permanent absence of rapid adaptation.