Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortex.
Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortex.
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精神分裂症的年龄和局部脑血流量：年龄对前扣带回、额叶和顶叶皮层的影响。
DOI：
10.1176/jnp.14.1.19
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Andreasen,NancyC
中科院分区：
文献类型：
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作者：
Schultz,SusanK;O'Leary,DanielS;BolesPonto,LauraL;Arndt,Stephan;Magnotta,Vincent;Watkins,GLeonard;Hichwa,RichardD;Andreasen,NancyC
应用正电子发射断层扫描（[15 O]水PET）研究精神分裂症患者年龄与局部脑血流量（rCBF）的关系。49名未用药的男性患者，年龄20-51岁，在闭眼休息状态下接受成像。年龄与双侧前扣带回、额叶（Brodmann区8）和顶叶皮层（区40）的rCBF呈负相关。随着年龄的增长，前扣带回中的rCBF减少的观察结果与健康受试者中的先前发现一致。相比之下，额叶和顶叶区域的血流减少可能是精神分裂症所特有的。
Positron emission tomography ([15O] water PET) was used to examine the relationship between age and regional cerebral blood flow (rCBF) in schizophrenia. Forty-nine unmedicated male patients, ages 20–51, underwent imaging during an eyes-closed resting condition. Negative correlations were observed between age and rCBF in the anterior cingulate, as well as in frontal (Brodmann area 8) and parietal cortex (area 40) bilaterally. The observation of reduced rCBF in the anterior cingulate with increased age is consistent with previous findings in healthy subjects. In contrast, the reduced flow observed in the frontal and parietal regions may be unique to schizophrenia.