Draxin Is Involved in the Proper Development of the dI3 Interneuron in Chick Spinal Cord
Draxin Is Involved in the Proper Development of the dI3 Interneuron in Chick Spinal Cord
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DOI：
10.1002/dvdy.22299
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发表时间：
2010-06-01
影响因子：
2.5
通讯作者：
Tanaka, Hideaki
中科院分区：
文献类型：
--
作者：
Su, Yuhong;Zhang, Sanbing;Tanaka, Hideaki
在神经系统发育过程中，产生适当类型、数量和分布的神经元需要仔细协调增殖、分化和模式。本研究分析了排斥性轴突引导蛋白draxin在鸡脊髓dI3中间神经元发育中的作用。draxin mRNA和/或蛋白首先在顶板中检测到，然后在鸡脊髓室性区与套性区的交界区和鸡脊髓背基底膜中检测到。draxin过表达导致dI3中间神经元迁移减少和延迟，祖细胞增殖减少，脊髓套带部分异位祖样细胞异常定位。我们的研究结果表明，德拉辛可能参与了鸡脊髓dI3中间神经元的正常发育。科学通报，2009(4):444 - 444。(C) 2010 Wiley-Liss, Inc。
Generation of the appropriate types, numbers and distribution of neurons during the development of the nervous system requires the careful coordination of proliferation, differentiation, and patterning. In this work, we analyzed the roles of a repulsive axon guidance protein, draxin, on the development of chick spinal cord dI3 interneuron. draxin mRNA and/or protein were detected in the roof plate at first and then the boundary region between the ventricular and the mantle zones in chick spinal cord and dorsal basement membrane of the chick spinal cord. Overexpression of draxin caused the decreased and delayed migration of the dI3 interneuron, the reduction of progenitor cell proliferation, and abnormal localization of some ectopic progenitor-like cells in the mantle zone of the spinal cord. Our data reveal that draxin may be involved in the proper development of the dI3 interneuron in chick spinal cord. Developmental Dynamics 239:1654-1663, 2010. (C) 2010 Wiley-Liss, Inc.