MicroRNAs as mediators of viral evasion of the immune system.
MicroRNAs as mediators of viral evasion of the immune system.
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作者：
细胞microRNA在几乎所有细胞基因调控途径的转录后调控中发挥关键作用，因此病毒找到破坏这一过程的方法并不奇怪。几种病毒编码直接下调先天免疫因子表达的微小RNA，包括参与促进细胞凋亡和募集免疫效应细胞的蛋白质。病毒还进化出下调或上调特定细胞miRNA以增强其复制的能力。这一观点概述了我们目前对病毒与细胞microRNA机制复杂相互作用的认识。
Cellular microRNAs play a key role in the post-transcriptional regulation of almost every cellular gene regulatory pathway and it therefore is not surprising that viruses have found ways to subvert this process. Several viruses encode microRNAs that directly downregulate the expression of innate immune factors, including proteins involved in promoting apoptosis and recruiting immune effector cells. Viruses have also evolved the ability to downregulate or upregulate specific cellular miRNAs in order to enhance their replication. This perspective provides an overview of our current knowledge of the complex interplay of viruses with the microRNA machinery of cells.
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