Chemoselective Pd(0)-catalyzed peptide coupling in water
Chemoselective Pd(0)-catalyzed peptide coupling in water
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DOI：
10.1021/ol016169e
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发表时间：
2001-08-09
期刊：
影响因子：
5.2
通讯作者：
Ghadiri, MR
中科院分区：
文献类型：
--
作者：
Bong, DT;Ghadiri, MR
在酸性（pH 5.0）和碱性（pH 7.5）条件下，使用Sonogashira Pd(0)偶联策略，将长度从17到33个残基的高电荷肽有效地三偶联到三烷基核上。这些结果证明了Pd(0)在水环境中构建蛋白质大小结构（12,000 mol wt）的效用。
[GRAPHICS]Highly charged peptides ranging In length from 17 to 33 residues have been efficiently tricoupled to a trialkyne nucleus by using a Sonogashira Pd(0) coupling strategy under both acidic (pH 5.0) and basic (pH 7.5) conditions. These results demonstrate the utility of Pd(0) to construct protein-sized structures (12,000 mol wt) in aqueous milieu.