IC3D Classification of Corneal Dystrophies-Edition 2
IC3D Classification of Corneal Dystrophies-Edition 2
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DOI：
10.1097/ico.0000000000000307
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发表时间：
2015-02-01
期刊：
影响因子：
2.8
通讯作者：
Lisch, Walter
中科院分区：
文献类型：
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作者：
Weiss, Jayne S.;Moller, Hans Ulrik;Lisch, Walter
目的：更新2008年国际角膜营养不良分类（IC 3D），纳入新的临床，组织病理学和遗传信息。方法：IC 3D审查了2008年至2014年期间发表的关于角膜营养不良的全球同行评审文章。利用这些信息，更新了角膜营养不良模板和解剖学分类。结果：在回顾角膜营养不良的细胞起源的基础上，提出了一种改良的解剖学分类，包括（1）上皮和上皮下营养不良，（2）上皮-间质TGFBI营养不良，（3）间质营养不良，（4）内皮营养不良。大多数营养不良模板已更新。“上皮复发性糜烂性营养不良”实际上包括许多潜在不同的上皮营养不良（Franceschetti角膜营养不良、Smolandiensis营养不良和Helsinglandica营养不良），但必须与营养不良（如TGF β 1诱导的营养不良）区分开来，后者通常也与复发性上皮糜烂相关。Thiel-Behnke角膜营养不良的染色体位点仅位于5 q31。先前被指定为Thiel-Behnke角膜营养不良的染色体10 q24上的变体的实体可能代表一种新的角膜营养不良。先天性遗传性内皮营养不良（CHED，以前CHED 2）很可能只是一种常染色体隐性遗传疾病。所谓的常染色体显性遗传CHED（以前的CHED 1）是不够独特的继续被认为是一个独特的角膜营养不良。回顾几乎所有已发表的病例，其描述似乎与一种与同一20号染色体位点（PPCD 1）相关的后部多形性角膜营养不良最相似。共聚焦显微镜也已成为一个有用的工具，揭示在体内功能的几个角膜营养不良，以前需要组织病理学检查，以明确diagnosis.Conclusions：IC 3D分类的修订包括更新的解剖分类角膜营养不良更准确地分类TGFBI营养不良，影响多个层，而不是局限于一个角膜层。典型的组织病理学和共焦图像已被添加到角膜营养不良模板。
Purpose: To update the 2008 International Classification of Corneal Dystrophies (IC3D) incorporating new clinical, histopathologic, and genetic information.Methods: The IC3D reviewed worldwide peer-reviewed articles for new information on corneal dystrophies published between 2008 and 2014. Using this information, corneal dystrophy templates and anatomic classification were updated. New clinical, histopathologic, and confocal photographs were added.Results: On the basis of revisiting the cellular origin of corneal dystrophy, a modified anatomic classification is proposed consisting of (1) epithelial and subepithelial dystrophies, (2) epithelial-stromal TGFBI dystrophies, (3) stromal dystrophies, and (4) endothelial dystrophies. Most of the dystrophy templates are updated. The entity "Epithelial recurrent erosion dystrophies" actually includes a number of potentially distinct epithelial dystrophies (Franceschetti corneal dystrophy, Dystrophia Smolandiensis, and Dystrophia Helsinglandica) but must be differentiated from dystrophies such as TGFBI-induced dystrophies, which are also often associated with recurrent epithelial erosions. The chromosome locus of Thiel-Behnke corneal dystrophy is only located on 5q31. The entity previously designated as a variant of Thiel-Behnke corneal dystrophy on chromosome 10q24 may represent a novel corneal dystrophy. Congenital hereditary endothelial dystrophy (CHED, formerly CHED2) is most likely only an autosomal recessive disorder. The so-called autosomal dominant inherited CHED (formerly CHED1) is insufficiently distinct to continue to be considered a unique corneal dystrophy. On review of almost all of the published cases, the description appeared most similar to a type of posterior polymorphous corneal dystrophy linked to the same chromosome 20 locus (PPCD1). Confocal microscopy also has emerged as a helpful tool to reveal in vivo features of several corneal dystrophies that previously required histopathologic examination to definitively diagnose.Conclusions: This revision of the IC3D classification includes an updated anatomic classification of corneal dystrophies more accurately classifying TGFBI dystrophies that affect multiple layers rather than are confined to one corneal layer. Typical histopathologic and confocal images have been added to the corneal dystrophy templates.