Amyloid imaging in cognitively normal older adults: comparison between 18F-flutemetamol and 11C-Pittsburgh compound B
Amyloid imaging in cognitively normal older adults: comparison between 18F-flutemetamol and 11C-Pittsburgh compound B
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DOI：
10.1007/s00259-015-3156-9
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发表时间：
2016-01-01
影响因子：
9.1
通讯作者：
Vandenberghe, Rik
中科院分区：
文献类型：
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作者：
Adamczuk, Katarzyna;Schaeverbeke, Jolien;Vandenberghe, Rik
目的临床前或无症状阿尔茨海默病（AD）是指在没有认知缺陷的情况下存在阳性AD生物标志物。这一研究概念正被应用于确定临床药物开发的目标人群。在一项前瞻性社区招募的认知功能完整的老年人队列中，我们比较了受试者中的两种淀粉样蛋白成像标记物：F-18-flutemetabine和C-11-Pittsburgh compound B（PI B）。方法在32名年龄在65岁至80岁之间的社区招募的认知完整的老年人中，根据半定量评估，我们确定了基于F-18-Flutemetamine与C-11-PIB的二元分类之间的一致性（复合皮质体积中的标准化摄取值比率，SUVRcomp），或者根据视觉读数。我们还确定了F-18-flutemetabine和C-11-PIB SUVR之间的相关性，并评估了这是如何受到影响的参考区域选择（小脑灰质与脑桥）和使用部分容积校正（PVC）在这个population.Results二进制分类的基础上半定量评估是一致的F-18-flutemetabine和C-11-PIB在94%的情况下。示踪剂之间盲法二进制视觉读数的一致性为84%。以小脑灰质为参考区域，F-18-flutemetratum和C-11-PIB SUVRcomp之间的斯皮尔曼相关性为0.84，斜率为0.98。以脑桥为参照区，新皮质区的相关性显著降低。结论以小脑灰质为参照区，用F-18-Flutemetransplantation半定量评估与C-11-PIB的一致性最高。
Purpose Preclinical, or asymptomatic, Alzheimer's disease (AD) refers to the presence of positive AD biomarkers in the absence of cognitive deficits. This research concept is being applied to define target populations for clinical drug development. In a prospective community-recruited cohort of cognitively intact older adults, we compared two amyloid imaging markers within subjects: F-18-flutemetamol and C-11-Pittsburgh compound B (PIB).Methods In 32 community-recruited cognitively intact older adults aged between 65 and 80 years, we determined the concordance between binary classification based on F-18-flutemetamol versus C-11-PIB according to semiquantitative assessment (standardized uptake value ratio in composite cortical volume, SUVRcomp) and, alternatively, according to visual reads. We also determined the correlation between F-18-flutemetamol and C-11-PIB SUVR and evaluated how this was affected by the reference region chosen (cerebellar grey matter versus pons) and the use of partial volume correction (PVC) in this population.Results Binary classification based on semiquantitative assessment was concordant between F-18-flutemetamol and C-11-PIB in 94 % of cases. Concordance of blinded binary visual reads between tracers was 84 %. The Spearman correlation between F-18-flutemetamol and C-11-PIB SUVRcomp with cerebellar grey matter as reference region was 0.84, with a slope of 0.98. Correlations in neocortical regions were significantly lower with the pons as reference region. PVC improved the correlation in striatum and medial temporal cortex.Conclusion For the definition of preclinical AD based on F-18-flutemetamol, concordance with C-11-PIB was highest using semiquantitative assessment with cerebellar grey matter as reference region.