LDOC1, a novel MZF-1-interacting protein, induces apoptosis
LDOC1, a novel MZF-1-interacting protein, induces apoptosis
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DOI：
10.1016/j.febslet.2004.12.030
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发表时间：
2005-01-31
期刊：
影响因子：
3.5
通讯作者：
Ra, C
中科院分区：
文献类型：
--
作者：
Inoue, M;Takahashi, K;Ra, C
1999年，LDOC 1作为编码亮氨酸拉链蛋白的基因被分离出来，该蛋白在胰腺癌和胃癌细胞系中的表达降低。在这里，我们发现LDOC 1的过度表达导致细胞膜磷脂酰丝氨酸的外化，这是早期凋亡事件的特征，并降低了一些人细胞系的细胞活力。凋亡过程是由线粒体膜电位的丧失引发的，导致caspase-3依赖性和非依赖性途径。此外，一个转录因子，MZF-1，被揭示与LDOC 1相互作用，并增强LDOC 1诱导凋亡的活性。(C)2004年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
LDOC1 was isolated as a gene encoding a leucine-zipper protein whose expression was decreased in pancreatic and gastric cancer cell lines in 1999. Here, we found that overexpression of LDOC1 caused externalization of the cell membrane phosphatidylserine, which was characteristic for early-phase apoptotic events, and reduced cell viability in some human cell lines. The apoptotic process was triggered by a loss of the mitochondrial membrane potential, leading to both caspase-3-dependent and -independent pathways. Furthermore, a transcription factor, MZF-1, was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.