Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans
Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans
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DOI：
10.1016/j.neuron.2020.02.012
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发表时间：
2020-05-20
期刊：
影响因子：
16.2
通讯作者：
Starr, Philip A.
中科院分区：
文献类型：
--
作者：
Chen, Witney;de Hemptinne, Coralie;Starr, Philip A.
动态改变运动输出的能力，例如停止启动的反应，是人类行为的一个重要方面。假设额下回和丘脑底核之间的超直接通路介导运动抑制，但在人类中这方面的证据有限。我们记录了21名受试者额下回和丘脑底核的高空间和时间分辨率场电位。丘脑底核刺激诱发的皮层电位显示短潜伏期事件，表明额下回和丘脑底核腹侧核之间的单突触连接。在一个停止信号任务，停止相关的电位在皮层之前停止相关的活动在丘脑底核，这些任务诱发电位之间的同步预测停止信号反应时间。因此，我们表明，前额叶-丘脑底超直接通路是存在于人类和介导的快速停止。这些发现可能为治疗运动抑制紊乱的治疗提供信息。
The ability to dynamically change motor outputs, such as stopping an initiated response, is an important aspect of human behavior. A hyperdirect pathway between the inferior frontal gyrus and subthalamic nucleus is hypothesized to mediate movement inhibition, but there is limited evidence for this in humans. We recorded high spatial and temporal resolution field potentials from both the inferior frontal gyms and subthalamic nucleus in 21 subjects. Cortical potentials evoked by subthalamic stimulation revealed short latency events indicative of monosynaptic connectivity between the inferior frontal gyrus and ventral subthalamic nucleus. During a stop signal task, stopping-related potentials in the cortex preceded stopping-related activity in the subthalamic nucleus, and synchronization between these task-evoked potentials predicted the stop signal reaction time. Thus, we show that a prefrontal-subthalamic hyperdirect pathway is present in humans and mediates rapid stopping. These findings may inform therapies to treat disorders featuring perturbed movement inhibition.