Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking.
Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking.
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DOI：
10.1115/1.4032124
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Elias Pavlatos;B. C. Perez;H. Morris;Hong Chen;Joel R. Palko;X. Pan;P. Weber;R. T. Hart;Jun Liu
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文献类型：
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作者：
Elias Pavlatos;B. C. Perez;H. Morris;Hong Chen;Joel R. Palko;X. Pan;P. Weber;R. T. Hart;Jun Liu
眼压（IOP）在乳头周围巩膜诱导菌株可能在青光眼的进展中起作用。采用膨胀测试和超声斑点跟踪，测量了9个人类供体球体乳头周围巩膜的三维应变。我们的研究结果表明，在膨胀期间，乳头周围巩膜经历了贯穿厚度的压缩和经向拉伸，而当IOP从10增加到19 mmHg时，观察到最小的周向扩张。最大剪切主要分布在贯穿厚度和经向截面，其大小略大于第一主应变。组织体积总体变化很小，证实了巩膜几乎不可压缩性。乳头周围区域存在大量的应变异质性，局部高应变区可能与穿越血管引起的结构异质性相对应。这些三维应变特征为IOP生理升高期间乳头周围巩膜的生物力学反应提供了新的见解。未来的研究需要证实这些发现，并调查这些生物力学特征在眼部疾病中的作用。
Intraocular pressure (IOP) induced strains in the peripapillary sclera may play a role in glaucoma progression. Using inflation testing and ultrasound speckle tracking, the 3D strains in the peripapillary sclera were measured in nine human donor globes. Our results showed that the peripapillary sclera experienced through-thickness compression and meridional stretch during inflation, while minimal circumferential dilation was observed when IOP was increased from 10 to 19 mmHg. The maximum shear was primarily oriented in the through-thickness, meridional cross sections and had a magnitude slightly larger than the first principal strain. The tissue volume had minimal overall change, confirming near-incompressibility of the sclera. Substantial strain heterogeneity was present in the peripapillary region, with local high strain areas likely corresponding to structural heterogeneity caused by traversing blood vessels. These 3D strain characteristics provide new insights into the biomechanical responses of the peripapillary sclera during physiological increases of IOP. Future studies are needed to confirm these findings and investigate the role of these biomechanical characteristics in ocular diseases.