Sex-Specific Associations Between Alcohol Consumption and Incidence of Hypertension: A Systematic Review and Meta-Analysis of Cohort Studies.
Sex-Specific Associations Between Alcohol Consumption and Incidence of Hypertension: A Systematic Review and Meta-Analysis of Cohort Studies.
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DOI：
10.1161/jaha.117.008202
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发表时间：
2018-06-27
影响因子：
5.4
通讯作者：
Rehm J
中科院分区：
文献类型：
--
作者：
Roerecke M;Tobe SW;Kaczorowski J;Bacon SL;Vafaei A;Hasan OSM;Krishnan RJ;Raifu AO;Rehm J
尽管大量饮酒会增加患高血压的风险这一事实已得到充分证实，但对于男性和女性来说，低水平饮酒与高血压的风险之间的关系尚不清楚。我们在Medline和Embase上搜索了关于平均酒精摄入量与非高血压人群高血压发病率之间关系的原始队列研究。进行随机效应meta分析和meta回归。来自20篇文章的数据包括361 254名参与者（125 907名男性和235 347名女性）和90 160例高血压事件（32 426名男性和57 734名女性）。在每天饮用1至2杯酒（每次饮用12克纯乙醇）的人群中，男性和女性的高血压发病率不同（女性对男性的相对风险=0.79；95%可信区间为0.67-0.93）。在男性中，与不饮酒者相比，每天饮用1至2杯、3至4杯和5杯以上标准饮料的相对危险度分别为1.19（1.07-1.31;2=59%）、1.51（1.30-1.76）和1.74（1.35-2.24）。在女性中，每天喝1到2杯酒的风险没有增加（相对风险=0.94;0.88-1.01;I2=73%），超过这个水平的风险增加（相对风险=1.42;1.22-1.66）。在男性中，任何酒精的摄入都会增加患高血压的风险。在女性中，每天喝1到2杯酒没有增加风险，但喝得越多风险就越大。与早期的荟萃分析相反，我们没有发现饮酒对女性有保护作用的证据。
Although it is well established that heavy alcohol consumption increases the risk of hypertension, the risk associated with low levels of alcohol intake in men and women is unclear. We searched Medline and Embase for original cohort studies on the association between average alcohol consumption and incidence of hypertension in people without hypertension. Random‐effects meta‐analyses and metaregressions were conducted. Data from 20 articles with 361 254 participants (125 907 men and 235 347 women) and 90 160 incident cases of hypertension (32 426 men and 57 734 women) were included. In people drinking 1 to 2 drinks/day (12 g of pure ethanol per drink), incidence of hypertension differed between men and women (relative riskwomen vs men=0.79; 95% confidence interval, 0.67–0.93). In men, the risk for hypertension in comparison with abstainers was relative risk=1.19 (1.07–1.31; I2=59%), 1.51 (1.30–1.76), and 1.74 (1.35–2.24) for consumption of 1 to 2, 3 to 4, and 5 or more standard drinks per day, respectively. In women, there was no increased risk for 1 to 2 drinks/day (relative risk=0.94; 0.88–1.01; I2=73%), and an increased risk for consumption beyond this level (relative risk=1.42; 1.22–1.66). Any alcohol consumption was associated with an increase in the risk for hypertension in men. In women, there was no risk increase for consumption of 1 to 2 drinks/day and an increased risk for higher consumption levels. We did not find evidence for a protective effect of alcohol consumption in women, contrary to earlier meta‐analyses.