Integrating new discoveries into the "vicious cycle" paradigm of prostate to bone metastases.
Integrating new discoveries into the "vicious cycle" paradigm of prostate to bone metastases.
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DOI：
10.1007/s10555-014-9494-4
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发表时间：
2014-09
影响因子：
9.2
通讯作者：
Lynch, Conor C.
中科院分区：
文献类型：
--
作者：
Cook, Leah M.;Shay, Gemma;Aruajo, Arturo;Lynch, Conor C.
In prostate to bone metastases, the “vicious cycle” paradigm has been traditionally used to illustrate how metastases manipulate the bone forming osteoblasts and resorbing osteoclasts in order to yield factors that facilitate the growth and establishment. However, recent advances have illustrated that the cycle is far more complex than this simple interpretation. In this review, we will discuss the role of exosomes and hematopoietic/mesenchymal stem cells facilitate the establishment and activation of prostate metastases and, how cells including such as myeloid derived suppressor cells, macrophages, T-cells and nerve cells contribute to the momentum of the vicious cycle. The increased complexity of the tumor-bone microenvironment requires a systems level approach. The evolution of computational models to interrogate the tumor-bone microenvironment is also discussed and the application of this integrated approach should allow for the development of effective therapies to treat and cure prostate to bone metastases.
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影响因子：
4
作者：
Ciovacco, Wendy A.;Cheng, Ying-Hua;Kacena, Melissa A.
通讯作者：
Kacena, Melissa A.
影响因子：
6.2
作者：
Alexander, Kylie A.;Chang, Ming K.;Pettit, Allison R.
通讯作者：
Pettit, Allison R.
影响因子：
6.5
作者：
Bord, S;Frith, E;Compston, JE
通讯作者：
Compston, JE
影响因子：
5.3
作者：
Coscia M;Quaglino E;Iezzi M;Curcio C;Pantaleoni F;Riganti C;Holen I;Mönkkönen H;Boccadoro M;Forni G;Musiani P;Bosia A;Cavallo F;Massaia M
通讯作者：
Massaia M
DOI：
10.1186/bcr3412
发表时间：
2013-04-11
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Das Roy L;Curry JM;Sahraei M;Besmer DM;Kidiyoor A;Gruber HE;Mukherjee P
通讯作者：
Mukherjee P