Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens.
Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens.
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DOI：
10.1155/2015/569367
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发表时间：
2015
影响因子：
--
通讯作者：
Takeuchi H
中科院分区：
文献类型：
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作者：
Fukuhara T;Matsuda E;Endo Y;Donishi R;Izawa S;Fujiwara K;Kitano H;Takeuchi H
我们试图通过在排除物理伪影的条件下精确评估切除标本的 5 × 5mm2 感兴趣区域 (ROI) 内的病理结构，来阐明剪切波速度 (SWV) 与甲状腺纤维化之间的相关性。材料为未选择的甲状腺手术期间切除的甲状腺和淋巴结标本。手术后立即将新鲜的未固定甲状腺和转移淋巴结标本悬浮在凝胶体模中，并测量 SWV。对每个标本进行病理检查，纤维化程度分为无、中度或重度。总共评估了 109 个标本：15 个正常甲状腺、16 个自身免疫性甲状腺炎、40 个恶性结节、19 个良性甲状腺结节和 19 个转移性淋巴结。当所有标本根据病理影像确定的纤维化程度进行分类时，无纤维化的平均SWV为1.49±0.39米/秒，中度纤维化的平均SWV为2.13±0.66米/秒，重度纤维化的平均SWV为2.68±0.82米/秒。中度和重度纤维化样本的SWV显着高于未纤维化样本。这项研究的结果表明，纤维化在确定甲状腺硬度（通过甲状腺 SWV 测量）方面起着重要作用。
We sought to elucidate the correlation between shear wave velocity (SWV) and fibrosis in thyroid by precisely assessing pathological structures inside 5 × 5 mm2 regions of interest (ROIs) of resected specimens, under conditions that excluded physical artifacts. The materials were unselected thyroid and lymph node specimens resected during thyroid surgery. Immediately after surgery, fresh unfixed thyroid and metastatic lymph node specimens were suspended in gel phantoms, and SWV was measured. Upon pathological examination of each specimen, the extent of fibrosis was graded as none, moderate, or severe. A total of 109 specimens were evaluated: 15 normal thyroid, 16 autoimmune thyroiditis, 40 malignant nodules, 19 benign thyroid nodules, and 19 metastatic lymph nodes. When all specimens were classified according to the degree of fibrosis determined by pathological imaging, the mean SWV was 1.49 ± 0.39 m/s for no fibrosis, 2.13 ± 0.66 m/s for moderate fibrosis, and 2.68 ± 0.82 m/s for severe fibrosis. The SWVs of samples with moderate and severe fibrosis were significantly higher than those of samples without fibrosis. The results of this study demonstrate that fibrosis plays an important role in determining stiffness, as measured by SWV in thyroid.