Effects of cannabinoids on host resistance to Listeria monocytogenes and herpes simplex virus
Effects of cannabinoids on host resistance to Listeria monocytogenes and herpes simplex virus
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大麻素对宿主对单核细胞增生李斯特菌和单纯疱疹病毒抵抗力的影响
DOI：
10.1128/iai.23.3.670-674.1979
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发表时间：
1979
影响因子：
3.1
通讯作者：
A. Munson
中科院分区：
文献类型：
--
作者：
P. Morahan;P. Klykken;S. Smith;L. Harris;A. Munson
我们实验室以前的研究表明，大麻素具有免疫抑制特性。本研究旨在确定这些药物是否降低宿主对单核细胞增生李斯特菌和单纯疱疹病毒2型感染的抵抗力。通过大麻素处理小鼠和对照小鼠中病原体50%致死剂量的变化来测量宿主抗性。研究了大麻素类物质对L.单核细胞增多症是剂量依赖性的。剂量为38、75和150 mg/kg的δ-9-四氢大麻酚分别抑制了10倍、17倍和657倍的感染抵抗力。马利筋提取物活性较低，但显著降低了对L.在所有测试剂量下的单核细胞基因。对系统性单纯疱疹病毒2型感染的抵抗力下降了96倍，由δ-9-四氢大麻酚，虽然大麻提取物是无效的。大麻素治疗的剂量和方案，产生显着降低宿主的抵抗力是相似的，引起抑制迟发型超敏反应的绵羊红细胞。讨论了大麻提取物及其大麻素降低宿主抗性的可能机制和公共卫生方面的问题。
Previous investigations from our laboratories have demonstrated that cannabinoids possess immunosuppressive properties. The present studies were designed to determine whether these agents decrease host resistance to infections with Listeria monocytogenes and herpes simplex virus type 2. Host resistance was measured by changes in the 50% lethal dose of the pathogen in cannabinoid-treated and control mice. The effect of cannabinoids on resistance to L. monocytogens was dose dependent. Delta-9-tetrhydrocannabinol at doses of 38, 75, and 150 mg/kg suppressed resistance to infection by 10-, 17-, and 657-fold, respectively. Marijuana extract was less active but significantly reduced resistance to L. moncytogenes at all tested doses. Resistance to systemic herpes simplex virus type 2 infection was decreased 96-fold by delta-9-tetrahydrocannabinol, although marijuana extract was inactive. The doses and regimen of treatment with cannabinoids that produced significant decreases in host resistance were similar to those which caused suppression of delayed-type hypersensitivity to sheep erythrocytes. The possible mechanisms and public health aspects of the decreased host resistance produced by marijuana extract and its cannabinoids are discussed.