Adiponectin Is a Candidate Biomarker of Lower Extremity Bone Density in Men With Chronic Spinal Cord Injury
Adiponectin Is a Candidate Biomarker of Lower Extremity Bone Density in Men With Chronic Spinal Cord Injury
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DOI：
10.1002/jbmr.2020
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发表时间：
2014-01-01
影响因子：
6.2
通讯作者：
Morse, Leslie R.
中科院分区：
文献类型：
--
作者：
Doherty, Ashley L.;Battaglino, Ricardo A.;Morse, Leslie R.
脂肪组织是骨代谢的主要调节器，并且在一般人群中，肥胖与更大的骨矿物质密度（BMD）相关。然而，骨-脂肪相互作用是多因素的，并且可能涉及影响骨形成和再吸收的途径，对骨骼具有竞争作用。其中一种途径涉及脂肪细胞产生调节骨代谢的脂肪因子。在这项研究中，我们确定了149名慢性脊髓损伤（SCI）男性患者的BMD、步行状态和循环脂肪因子（脂联素和瘦素）之间的关系。虽然脂肪因子水平没有显着变化的基础上行走状态，有一个显着的负相关性脂联素和BMD轮椅使用者的身体成分独立。我们发现步行者的脂联素和BMD之间没有关联，两组的瘦素和BMD之间也没有关联。这些发现表明，对于慢性SCI受试者，步行可能会减轻脂联素介导的骨丢失的影响。对于轮椅使用者，脂肪源性脂联素可能有助于SCI诱导的骨质疏松症，因为肥胖的骨保护作用似乎需要在截肢期间的机械负荷。(c)2014年美国骨与矿物质研究学会。
Adipose tissue is a major regulator of bone metabolism and in the general population obesity is associated with greater bone mineral density (BMD). However, bone-fat interactions are multifactorial, and may involve pathways that influence both bone formation and resorption with competing effects on the skeleton. One such pathway involves adipocyte production of adipokines that regulate bone metabolism. In this study we determined the association between BMD, walking status, and circulating adipokines (adiponectin and leptin) in 149 men with chronic spinal cord injury (SCI). Although adipokine levels did not vary significantly based on walking status, there was a significant inverse association between adiponectin and BMD in wheelchair users independent of body composition. We found no association between adiponectin and BMD in the walkers and no association between leptin and BMD in either group. These findings suggest that for subjects with chronic SCI, walking may mitigate the effect of adiponectin mediated bone loss. For wheelchair users, adipose-derived adiponectin may contribute to SCI-induced osteoporosis because the osteoprotective benefits of obesity appear to require mechanical loading during ambulation. (c) 2014 American Society for Bone and Mineral Research.