Cytotoxic hydrolyzable tannins from Balanophora japonica
Cytotoxic hydrolyzable tannins from Balanophora japonica
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DOI：
10.1021/np070519
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发表时间：
2008-04-01
影响因子：
5.1
通讯作者：
Kouno, Isao
中科院分区：
文献类型：
--
作者：
Jiang, Zhi-Hong;Wen, Xiao-Yun;Kouno, Isao
从寄生植物日本蛇菰（Balanophora japonica）的地上部分分离得到4种水解单宁，命名为蛇菰单宁D-G（1-4）。它们的结构特征的基础上，光谱和化学证据。Balanophotannins D-G含有氧化的六羟基二苯甲酰基（HHDP）基团。用PGME法测定了藤壶单宁D（1）和F（3）的绝对构型。Balanophotannin E（2）对Hep，G2癌细胞具有细胞毒性，IC（50）值为4.22 μ M。
Four hydrolyzable tannins named balanophotannins D-G (1-4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D (1) and F (3) were determined via the PGME method. Balanophotannin E (2) showed cytotoxicity to Hep, G2 cancer cells with an IC(50) value of 4.22 mu M.