Photoinduced Dynamic Radical Processes for Isomerizations, Deracemizations, and Dynamic Kinetic Resolutions
Photoinduced Dynamic Radical Processes for Isomerizations, Deracemizations, and Dynamic Kinetic Resolutions
复制标题
DOI：
10.1021/acscatal.2c02480
复制
发表时间：
2022-07-11
期刊：
影响因子：
12.9
通讯作者：
Hyster, Todd K.
中科院分区：
文献类型：
--
作者：
DeHovitz, Jacob S.;Hyster, Todd K.
异构化是一种化学过程，其中一种化合物转化为另一种结构，同时保持相同的化学式。当动态时，这些反应服从收敛的合成场景，其中一个异构体在随后的化学步骤中优先反应或作为异构化机理的函数而积累。随着最近光化学的复兴，利用自由基和双自由基作为异构化关键中间体的转化数量急剧增加。这一观点将考察异构化、去消旋化和动态动力学拆分中的这些动态方法。通过更好地了解这些方法使用的机制，可以想象动态过程可以简化化学合成。
Isomerizations are chemical processes where a compound is transformed into another structure while retaining the same chemical formula. When dynamic, these reactions are amenable to convergent synthetic scenarios where one isomer reacts preferentially in a subsequent chemical step or accumulates as a function of the isomerization mechanism. With the recent renaissance of photochemistry, there has been a dramatic increase in the number of transformations leveraging radicals and diradicals as key intermediates for isomerization. This perspective will examine these dynamic approaches in isomerizations, deracemizations, and dynamic kinetic resolutions. By better understanding the mechanisms these approaches employ, dynamic processes can be imagined that could streamline chemical synthesis.