Effects of early life social stress on endocrinology, maternal behavior, and lactation in rats
Effects of early life social stress on endocrinology, maternal behavior, and lactation in rats
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DOI：
10.1016/j.yhbeh.2013.08.011
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发表时间：
2013-09-01
影响因子：
3.5
通讯作者：
Nephew, Benjamin C.
中科院分区：
文献类型：
--
作者：
Carini, Lindsay M.;Nephew, Benjamin C.
早期生活压力是精神健康障碍的预测因素，早期生活压力的两种常见形式是社会冲突和母亲护理受损，这是产后情绪障碍的主要特征。将哺乳期雌性大鼠暴露在一种新的雄性入侵者面前会引起强烈的社会冲突，并导致对F1后代的母体护理不足。这种暴露对雌性F1幼崽是一种早期的社会应激源，它会导致成年F1雌性雌性催产素(OXT)、催乳素(PRL)和精氨酸加压素(AVP)基因表达的中枢变化，从而导致低效哺乳。在本研究中，大鼠的母亲被允许在不暴露于社会应激源的情况下抚养幼鼠(对照组)，或者在哺乳期第2-16天每天向一只新的雄性入侵者呈现1小时(慢性社会应激)。将雌性幼崽暴露在早期社会应激环境中，导致哺乳末期母体内分泌持续变化(催乳素减弱和皮质酮升高)，母体关怀和攻击性降低，躁动和焦虑相关行为增加，哺乳功能受损，糖精偏好降低。内分泌和行为数据表明，早期生活的CS具有类似于抑郁症母亲临床人群中看到的变化的长期影响，并为使用慢性社会应激范式作为产后抑郁和焦虑等母体疾病的行为学相关啮齿动物模型提供支持。(C)2013 Elsevier Inc.保留所有权利。
Exposure to early life stress is a predictor of mental health disorders, and two common forms of early life stress are social conflict and impaired maternal care, which are predominant features of postpartum mood disorders. Exposure of lactating female rats to a novel male intruder involves robust social conflict and induces deficits in maternal care towards the F1 offspring. This exposure is an early life social stressor for female F1 pups that induces inefficient lactation associated with central changes in oxytocin (OXT), prolactin (PRL), and arginine vasopressin (AVP) gene expression in adult F1 females.The mothers of the rats in the current study were either allowed to raise their pups without exposure to a social stressor (control), or presented with a novel male intruder for 1 h each day on lactation days 2-16 (chronic social stress). The effects of this early life chronic social stress (CSS) exposure on subsequent peripheral endocrinology, maternal behavior, and physiology were assessed.Exposure of female pups to early life CSS resulted in persistent alterations in maternal endocrinology at the end of lactation (attenuated prolactin and elevated corticosterone), depressed maternal care and aggression, increased restlessness and anxiety-related behavior, impaired lactation, and decreased saccharin preference. The endocrine and behavioral data indicate that early life CSS has long-term effects which are similar to changes seen in clinical populations of depressed mothers and provide support for the use of the chronic social stress paradigm as an ethologically relevant rodent model for maternal disorders such as postpartum depression and anxiety. (C) 2013 Elsevier Inc. All rights reserved.