No evidence for an mtDNA role in sperm motility:: Data from complete sequencing of asthenozoospermic males
No evidence for an mtDNA role in sperm motility:: Data from complete sequencing of asthenozoospermic males
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DOI：
10.1093/molbev/msm004
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发表时间：
2007-03-01
影响因子：
10.7
通讯作者：
Macaulay, Vincent
中科院分区：
文献类型：
--
作者：
Pereira, Luisa;Goncalves, Joao;Macaulay, Vincent
第一个完整的线粒体DNA（mtDNA）序列（类似于16,569 bp）在20例弱精子症患者和23个新的完整的mtDNA序列在畸形弱精子症个体的比较，证实没有共享特定的多态性或特定的线粒体谱系这些个体之间。这是一个强有力的证据，反驳了mtDNA在男性生育力中发挥重要作用的公认说法，这种说法曾得到基于高变区I筛选的单倍群关联研究的支持。因此，必须谨慎对待母系驱动的选择作用于男性生殖成功的假设。
The first complete mitochondrial DNA (mtDNA) sequences (similar to 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.