Rare renal metastases from differentiated thyroid carcinoma: early clinical detection and treatment based on radioiodine.
Rare renal metastases from differentiated thyroid carcinoma: early clinical detection and treatment based on radioiodine.
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分化型甲状腺癌的罕见肾转移：基于放射性碘的早期临床检测和治疗。
DOI：
10.1590/0004-2730000002913
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
罗全勇
中科院分区：
文献类型：
--
作者：
邱忠领;薛艳丽;罗全勇
客观化
本研究旨在探讨14例分化型甲状腺癌(DTC)肾转移癌的临床特点、~(131)I检测方法及~(131)I治疗的疗效。
研究对象和方法
对2955例接受~(131)I治疗的DTC患者进行了回顾性分析。口服治疗剂量131I后，分别行~(131)I-WBS、~(31)I-SPECT/CT和(或)~(18)F-FDG-PET/CT扫描，根据TG变化和肾脏病变的解剖影像变化评价疗效。
结果
14例患者中有11例对~(131)I有亲和力，但有3例治疗后未蓄积~(131)I。在11个(131)I-SPECT/CT阳性的肾脏病变中，有10例是通过~(131)I-SPECT/CT联合其他显像发现的，1例是~(131)I-WBS结合超声(US)发现的。在3个~(131)I阴性的肾脏病变中，2例经18F-FDG-PET/CT发现，1例经CT检查发现。在11例~(131)I肾转移患者中，81.82%(9/11)的患者血清甘油三酯水平逐渐下降，18.18%(2/11)的患者血清甘油三酯水平明显升高。末次131I治疗前血清甘油三酯差异无统计学意义(Z=0.157；P=0.875)。只有一名患者出现部分缓解，八名患者病情稳定，两名病情进展的患者出现肾转移。没有患者达到完全缓解。
结论
(131)I-SPECT/CT结合~(131)I-WBS后的另一种显像方法有助于早期发现DTC的肾转移。(131)~(131)I治疗是治疗大多数DTC肾转移瘤的一种可行而有效的治疗方法。
OBJECTIVE
The aim of this study was to explore the clinical characteristics of renal metastatic cancer, the methods for its detection by radioiodine (131)I, and the response to (131)I treatment in fourteen patients with renal metastases from differentiated thyroid carcinoma (DTC).
SUBJECTS AND METHODS
DTC patients (n = 2,955) that received treatment with (131)I were retrospectively analyzed. Scans ((131)I-WBS, (31)I-SPECT/CT and/or (18)F-FDG-PET/CT) were performed after an oral therapeutic dose of (131)I. Therapeutic efficacy was evaluated based on changes in Tg and anatomical imaging changes at renal lesions.
RESULTS
Among these 14 patients, 11 had avidity for (131)I, but three patients did not accumulate (131)I after (131)I treatment. In the 11 (131)I-positive renal lesions, 10 cases were detected by (131)I-SPECT/CT combined with another imaging modality and one case by (131)I-WBS combined with ultrasonography (US). In the three (131)I-negative renal lesions, two cases were detected by 18F-FDG-PET/CT and one case by computed tomography (CT). In 11 patients with (131)I-avid renal metastases, Serum Tg levels in 81.82% (9/11) patients showed a gradual decline, and 18.18% (2/11) of the patients showed a significant elevation. There was no marked difference in serum Tg before the last (131)I treatment (Z = 0.157; p = 0.875). Only one patient presented partial response, eight patients exhibited stable disease, and renal metastases progressed in two patients showing progressive disease. No patients reached complete response.
CONCLUSION
(131)I-SPECT/CT, combined with another imaging modality after (131)I-WBS, can contribute to the early detection of renal metastases of DTC. (131)I therapy is a feasible and effective treatment for most DTC renal metastases with avidity for (131)I.
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DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
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作者：
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通讯作者：
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发表时间：
1995-08
期刊：
The American surgeon
影响因子：
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发表时间：
1999
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Annales d'urologie
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A. Benchekroun;A. Lachkar;M. Alami;A. Iken;A. Soumana;M. Farih;Z. Belahnech;M. Marzouk;M. Faik