Inhibitory Neuron Transplantation into Adult Visual Cortex Creates a New Critical Period that Rescues Impaired Vision.
Inhibitory Neuron Transplantation into Adult Visual Cortex Creates a New Critical Period that Rescues Impaired Vision.
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DOI：
10.1016/j.neuron.2015.03.062
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发表时间：
2015-05-20
期刊：
影响因子：
16.2
通讯作者：
Gandhi, Sunil P.
中科院分区：
文献类型：
--
作者：
Davis, Melissa F.;Velez, Dario X. Figueroa;Guevarra, Roblen P.;Yang, Michael C.;Habeeb, Mariyam;Carathedathu, Mathew C.;Gandhi, Sunil P.
幼年皮质抑制回路的成熟触发了视觉系统发育的可塑性关键期。虽然有几种抑制方法可以改变其时间，但没有一种方法可以重新激活成年期的关键期可塑性。我们开发了一种移植方法来重新激活成人视觉皮层的关键期可塑性。从内侧神经节隆起移植的胚胎抑制性神经元可恢复成年受者的眼优势可塑性。移植的抑制细胞发育出适合细胞类型的分子特征和视觉诱发反应。在幼年关键期因剥夺而受损的成年小鼠，移植也能恢复视觉皮质反应和视力行为测试的表现。当供体动物出现临界时期时，可塑性和恢复被诱导。这些结果表明，使用抑制性细胞移植的视觉皮质可塑性的局灶性再激活创造了一个新的关键期，恢复儿童剥夺后的视觉知觉。
The maturation of inhibitory circuits in the juvenile cortex triggers a critical period of plasticity in visual system development. Although several manipulations of inhibition can alter its timing, none have reactivated critical period plasticity in adulthood. We developed a transplantation method to reactivate critical period plasticity in the adult visual cortex. Transplanted embryonic inhibitory neurons from the medial ganglionic eminence reinstate ocular dominance plasticity in adult recipients. Transplanted inhibitory cells develop cell-type appropriate molecular characteristics and visually evoked responses. In adult mice impaired by deprivation during the juvenile critical period, transplantation also recovers both visual cortical responses and performance on a behavioral test of visual acuity. Plasticity and recovery are induced when the critical period would have occurred in the donor animal. These results reveal that the focal reactivation of visual cortical plasticity using inhibitory cell transplantation creates a new critical period that restores visual perception after childhood deprivation.
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