Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity
Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity
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DOI：
10.3109/17435390.2011.626535
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发表时间：
2012-12-01
期刊：
影响因子：
5
通讯作者：
Donaldson, Ken
中科院分区：
文献类型：
--
作者：
Poland, Craig A.;Byrne, Fiona;Donaldson, Ken
纤维状纳米材料在商业应用中的使用引起了人们的担忧，即它们可能会造成类似于某些形式的石棉等致病纤维的健康影响。在形成纤维致病性范式的属性中，纤维长度被认为是决定纤维毒性的关键因素。我们以前已经证明，碳纳米管表现出这种长度依赖的致病性，但目前尚不清楚其他形式的纤维纳米材料是否符合纤维致病性范式。因此，我们的目的是通过询问一种截然不同的纤维纳米材料镍纳米线是否显示出长度相关的致病性来确定这一假说的普遍性。我们的结果表明，以长镍纳米线(-gt；20微米)为主的镍纳米线能够以剂量依赖的方式在小鼠腹膜模型中引发强烈的炎症；而短(-gt；20微米)的镍纳米线未见炎症或纤维化。
The use of fibre-shaped nanomaterials in commercial applications has met with concern that they could cause health effects similar to those seen with pathogenic fibres such as certain forms of asbestos. Of the attributes which form the fibre pathogenicity paradigm, fibre length is thought to be a critical factor in determining fibre toxicity. We have previously shown that carbon nanotubes display such length-dependent pathogenicity but it remains unclear if other forms of fibrous nanomaterials conform to the fibre pathogenicity paradigm. As such, our aim is to determine the generality of this hypothesis by asking whether a radically different form of fibrous nanomaterial, nickel nanowires, show length-dependent pathogenicity. Our results indicate that nickel nanowires synthesised to be predominantly long (>20 mu m) show the ability to elicit strong inflammation in the mouse peritoneal model in a dose-dependent manner; inflammation or fibrosis was not seen with the short (