Calcium-calmodulin-dependent protein kinase IV is required for fear memory
Calcium-calmodulin-dependent protein kinase IV is required for fear memory
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DOI：
10.1038/nn0602-855
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发表时间：
2002-06-01
影响因子：
25
通讯作者：
Zhuo, M
中科院分区：
文献类型：
--
作者：
Wei, F;Qiu, CS;Zhuo, M
记住环境中潜在危险的能力对于动物和人类的生存是必要的。环腺苷酸反应元件结合蛋白（CREB）是突触可塑性和记忆巩固的关键转录因子。我们已经发现，在CaMKIV-/-小鼠中，缺乏钙-钙调蛋白依赖性蛋白激酶（CaMK）途径的一个组分，CREB激活的主要途径-恐惧记忆，但不持续疼痛，显着减少。CREB激活恐惧条件反射和突触增强杏仁核和皮质区减少或阻断。我们认为，与伤害性休克有关的认知记忆可以与组织损伤和炎症的行为反应分离。
The ability to remember potential dangers in an environment is necessary to the survival of animals and humans. The cyclic AMP-responsive element binding protein (CREB) is a key transcription factor in synaptic plasticity and memory consolidation. We have found that in CaMKIV-/- mice-which are deficient in a component of the calcium-calmodulin-dependent protein kinase (CaMK) pathway, a major pathway of CREB activation-fear memory, but not persistent pain, was significantly reduced. CREB activation by fear conditioning and synaptic potentiation in the amygdala and cortical areas was reduced or blocked. We propose that cognitive memory related to a noxious shock can be disassociated from behavioral responses to tissue injury and inflammation.