CHANGES IN CHOLESTERYL ESTER TRANSFER PROTEIN-ACTIVITY DURING NORMAL GESTATION AND POSTPARTUM
CHANGES IN CHOLESTERYL ESTER TRANSFER PROTEIN-ACTIVITY DURING NORMAL GESTATION AND POSTPARTUM
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DOI：
10.1016/0009-9120(94)90013-2
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发表时间：
1994-02-01
影响因子：
2.8
通讯作者：
LASUNCION, MA
中科院分区：
文献类型：
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作者：
IGLESIAS, A;MONTELONGO, A;LASUNCION, MA
胆固醇酯转移蛋白（CETP）活性测定在d > 1.21 kg/L的血浆部分收集健康妇女在不同时间在怀孕期间，产后，并在对照组妇女。CETP活性在妊娠中期最高，在妊娠晚期下降，产后最低。只有在第二个三个月的值是显着不同的控制妇女。这一趋势与循环脂蛋白不同：极低密度脂蛋白（VLDL）脂质，包括甘油三酯和胆固醇，从第一个到第三个三个月逐渐增加，然后在产后下降。低密度脂蛋白（LDL）胆固醇水平，像极低密度脂蛋白水平，在怀孕期间上升，但在产后保持升高。高密度脂蛋白（HDL）-胆固醇以及HDL-磷脂和载脂蛋白A-I在妊娠中期达到峰值，在妊娠晚期保持升高，然后在产后下降。最后，HDL-甘油三酯显着增加，从第一到第二个三个月，上升略高，在第三个三个月，并在产后下降。当所有的样本从孕妇一起考虑，CETP活性与HDL-甘油三酯水平显着相关，并在CETP活性的变化在妊娠期间和产后HDL-甘油三酯/VLDL-甘油三酯比值的变化。这些结果表明，CETP有助于在人类妊娠中期开始的HDL中甘油三酯的过度积累。
Cholesteryl ester transfer protein (CETP) activity was measured in a d > 1.21 kg/L plasma fraction collected from healthy women at different times during gestation, postpartum, and in control women. CETP activity was highest in the second trimester of gestation, declined at the third trimester, and was lowest at postpartum. Only the value at the second trimester was significantly different from that of control women. This trend differed from that of circulating lipoproteins: very low-density lipoprotein (VLDL)-lipids, including triglycerides and cholesterol, increased progressively from the first to the third trimester, and then declined at postpartum. Low-density lipoprotein (LDL)cholesterol levels, like VLDL levels, rose during gestation but then remained elevated at postpartum. High-density lipoprotein (HDL)-cholesterol as well as HDL-phospholipids and apolipoprotein A-l, peaked in the second trimester, remaining elevated in the third trimester and then fell at postpartum. Finally, HDL-triglyceride increased markedly from the first to the second trimester, rose somewhat higher during the third trimester, and declined at postpartum. When all the samples from pregnant women were considered together, CETP activity correlated significantly with HDL-triglyceride levels and the changes in CETP activity during gestation and postpartum paralleled those of the HDL-triglyceride/VLDL-triglyceride ratio. These results suggest that CETP contributes to the exaggerated accumulation of triglycerides in HDL that begins in the second trimester of human gestation.