The Ventral and Inferolateral Aspects of the Anterior Temporal Lobe Are Crucial in Semantic Memory: Evidence from a Novel Direct Comparison of Distortion-Corrected fMRI, rTMS, and Semantic Dementia
The Ventral and Inferolateral Aspects of the Anterior Temporal Lobe Are Crucial in Semantic Memory: Evidence from a Novel Direct Comparison of Distortion-Corrected fMRI, rTMS, and Semantic Dementia
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DOI：
10.1093/cercor/bhq019
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发表时间：
2010-11-01
期刊：
影响因子：
3.7
通讯作者：
Ralph, Matthew A. Lambon
中科院分区：
文献类型：
--
作者：
Binney, Richard J.;Embleton, Karl V.;Ralph, Matthew A. Lambon
虽然有一个新兴的共识，即前颞叶（ATLs）参与语义记忆，目前还不清楚这一地区的具体部分涉及语义表征。从现有文献中很难收集到这个问题的答案，原因有三：1）相关患者组的病变倾向于涵盖整个ATL区域; 2）虽然重复经颅磁刺激（rTMS）的局部效应在空间上更具特异性，但只有ATL的侧面可用于刺激;以及3）直到最近，功能性磁共振成像（fMRI）研究受到技术限制的阻碍，例如由于磁不均匀性引起的信号失真和丢失，并且在某些情况下，还受到方法学因素的阻碍，包括受限的视场和用于减影分析的基线对比度的选择。通过在正常受试者中使用语义痴呆，rTMS和畸变校正fMRI的相同语义任务，我们首次直接比较了3种方法的结果。研究结果是高度收敛的，并表明，在ATL的语义表征的关键区域包括前颞下回，前梭状回，和前上级颞沟。
Although there is an emerging consensus that the anterior temporal lobes (ATLs) are involved in semantic memory, it is currently unclear which specific parts of this region are implicated in semantic representation. Answers to this question are difficult to glean from the existing literature for 3 reasons: 1) lesions of relevant patient groups tend to encompass the whole ATL region; 2) while local effects of repetitive transcranial magnetic stimulation (rTMS) are spatially more specific, only the lateral aspects of the ATL are available to stimulation; and 3) until recently, functional magnetic resonance imaging (fMRI) studies were hindered by technical limitations such as signal distortion and dropout due to magnetic inhomogeneities and also, in some cases, by methodological factors, including a restricted field of view and the choice of baseline contrast for subtraction analysis. By utilizing the same semantic task across semantic dementia, rTMS, and distortion-corrected fMRI in normal participants, we directly compared the results across the 3 methods for the first time. The findings were highly convergent and indicated that crucial regions within the ATL for semantic representation include the anterior inferior temporal gyrus, anterior fusiform gyrus, and the anterior superior temporal sulcus.