ADRENARCHE - PROLACTIN, GONADOTROPINS, ADRENAL ANDROGENS, AND CORTISOL
ADRENARCHE - PROLACTIN, GONADOTROPINS, ADRENAL ANDROGENS, AND CORTISOL
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DOI：
10.1210/jcem-46-3-396
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发表时间：
1978-01-01
影响因子：
5.8
通讯作者：
ODELL, WD
中科院分区：
文献类型：
--
作者：
PARKER, LN;SACK, J;ODELL, WD
为了研究肾上腺初显，测定PRL [催乳素]、FSH [促卵泡激素]、LH [促黄体激素]、雄烯二酮、11 β-在106名2-12岁的儿童和成人中定量测定了羟雄烯二酮（11 β A）、脱氢表雄酮、脱氢表雄酮硫酸盐和皮质醇，以前没有报道过在大组青春期前儿童中PRL和11 β A的年龄。PRL、皮质醇和11 β A在这些年中没有显示出显著的变化。雄烯二酮是目前在相对较高的浓度在最年轻的年龄，并逐渐增加，而FSH和LH上升围青春期在11岁和12岁。与此相反，脱氢表雄酮及其硫酸盐表现出随着年龄的男孩和女孩的2阶段增加，与最大的相对变化发生在脱氢表雄酮硫酸盐浓度在2岁和5岁之间的女孩。肾上腺雄激素分泌的显著变化发生在两性青春期性腺变化之前。Δ 4类固醇A和11 β A在最年幼的儿童中以相对高的浓度存在，而Δ 5类固醇脱氢表雄酮和脱氢表雄酮硫酸盐的浓度倾向于随着年龄的增加而迅速增加，在最年幼的儿童中从相对低的值开始。Δ 4/Δ 5类固醇浓度比随着年龄的增长而逐渐降低。这表明3 β的早期突出。醇异构酶脱氢酶活性。这些数据表明，PRL在人体中控制肾上腺初显的作用很小或没有作用。
In order to study the adrenarche, serum concentrations of PRL [prolactin], FSH [follicle stimulating hormone], LH [luteinizing hormone], androstenedione, 11.beta.-hydroxyandrostenedione (11.beta.A), dehydroepiandrosterone, dehydroepiandrosterone sulfate and cortisol were quantified in 106 children from 2-12 yr of age and in adults, PRL and 11.beta.A have not previously been reported in a large group of prepubertal children with respect to age. PRL, cortisol and 11.beta.A showed no significant changes during these years. Androstenedione was present in relatively high concentrations at the youngest age and increased gradually, whereas FSH and LH rose peripubertally at ages 11 and 12. In contrast, dehydroepiandrosterone and its sulfate showed a progressive increase with age in boys and a 2 phase increase in girls, with the greatest relative change in the dehydroepiandrosterone sulfate concentration occurring between ages 2 and 5 in girls. Significant changes in adrenal androgen secretion occur well before the gonadal changes of puberty in both sexes. The .DELTA.4 steroids A and 11.beta.A were present in relatively high concentrations in the youngest children, whereas the .DELTA.5 steroids dehydroepiandrosterone and dehydroepiandrosterone sulfate tended to increase rapidly in concentration with increasing age beginning with relatively low values in the youngest children. The .DELTA.4/.DELTA.5 steroid concentration ratio decreased progressively with age. This indicates early prominence of 3.beta.-ol-isomerase dehydrogenase activity. The data suggest PRL has little or no role in the human in control of adrenarche.