Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction.
Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction.
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DOI：
10.1093/ajcn/82.1.163
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发表时间：
2005-07
期刊：
影响因子：
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通讯作者：
T. Fung;M. McCullough;P. Newby;J. Manson;James B. Meigs;N. Rifai;W. Willett;Frank B. Hu
中科院分区：
文献类型：
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作者：
T. Fung;M. McCullough;P. Newby;J. Manson;James B. Meigs;N. Rifai;W. Willett;Frank B. Hu
背景
内皮功能障碍是与心血管疾病风险增加相关的机制之一。
目的
我们评估了几种饮食质量评分与炎症和内皮功能障碍标志物血浆浓度之间的关联。
设计
通过使用1990年对护士健康研究中的690名女性（年龄43 - 69岁，无心血管疾病或糖尿病）进行的食物频率问卷调查，计算了健康饮食指数（HEI）、替代健康饮食指数（AHEI）、修订版饮食质量指数（DQI - R）、推荐食物评分（RFS）以及替代地中海饮食指数（aMED）的饮食质量评分。同年完成血液采集。我们使用回归分析来评估这些饮食质量评分与C - 反应蛋白、白细胞介素6、E - 选择素、可溶性细胞间黏附分子1和可溶性血管细胞黏附分子1的血浆浓度之间的关联。
结果
各种饮食质量评分之间显著相关；相关系数在0.56到0.80之间（所有P值<0.0001）。在对年龄、体重指数、酒精摄入量、体力活动、吸烟状况和能量摄入进行调整后，HEI和DQI - R与任何生物标志物均无显著关联，而AHEI和aMED评分与大多数生物标志物的浓度显著降低相关。RFS仅与E - 选择素浓度降低显著相关。AHEI和aMED最高五分位数组的C - 反应蛋白浓度分别比最低五分位数组低30%（P <0.05）和24%（P <0.05）。
结论
较高的AHEI和aMED评分与炎症和内皮功能障碍生物标志物浓度较低相关，因此可能作为降低涉及此类生物学途径疾病风险的有用指南。
BACKGROUND Endothelial dysfunction is one of the mechanisms linked to an increased risk of cardiovascular disease. OBJECTIVE We assessed the association between several diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction. DESIGN Diet-quality scores on the Healthy Eating Index (HEI), Alternate Healthy Eating Index (AHEI), Diet Quality Index Revised (DQI-R), Recommended Food Score (RFS), and the alternate Mediterranean Diet Index (aMED) were calculated by using a food-frequency questionnaire that was administered in 1990 to 690 women in the Nurses' Health Study (ages 43-69 y, no cardiovascular disease or diabetes). Blood collection was completed in the same year. We used regression analysis to assess the associations between these diet-quality scores and plasma concentrations of C-reactive protein, interleukin 6, E-selectin, soluble intercellular cell adhesion molecule 1, and soluble vascular cell adhesion molecule 1. RESULTS The various diet-quality scores were significantly correlated with each other; correlation coefficients ranged from 0.56 to 0.80 (all P values < 0.0001). After adjustment for age, body mass index, alcohol intake, physical activity, smoking status, and energy intake, the HEI and DQI-R were not significantly associated with any of the biomarkers, whereas the AHEI and aMED scores were associated with significantly lower concentrations of most biomarkers. The RFS was significantly associated with a lower concentration of E-selectin only. C-reactive protein concentrations were 30% (P < 0.05) and 24% (P < 0.05) lower in the top than in the bottom quintile of the AHEI and of the aMED, respectively CONCLUSION Higher AHEI and aMED scores were associated with lower concentrations of biomarkers of inflammation and endothelial dysfunction and therefore may be useful as guidelines for reducing the risk of diseases involving such biological pathways.