IN-VIVO SETTING BEHAVIOR OF FAST-SETTING CALCIUM-PHOSPHATE CEMENT
IN-VIVO SETTING BEHAVIOR OF FAST-SETTING CALCIUM-PHOSPHATE CEMENT
复制标题
DOI：
10.1016/0142-9612(95)94147-d
复制
发表时间：
1995-07-01
期刊：
影响因子：
14
通讯作者：
ASAOKA, K
中科院分区：
文献类型：
--
作者：
MIYAMOTO, Y;ISHIKAWA, K;ASAOKA, K
本文研究了快凝磷酸钙骨水泥（FSCPC）在大鼠股肌间的体内固化行为，以评价FSCPC在医学和牙科应用中的可能价值。将传统CPC（c-CPC）和FSCPC植入股肌之间，分别通过维卡针法、直径拉伸强度（DTS）测量和定量粉末X射线衍射（XRD）分析来测量凝固行为的各个方面，例如凝固时间、机械强度和骨水泥转化为羟基磷灰石（HAP：Ca-10（PO 4）（6）（OH）（2））的转化率。FSCPC在体内的凝固时间为5-7 min，而c-CPC为48 min。由于其快速凝固，FSCPC的凝固试样从初始阶段就表现出比c-GPC更高的机械强度。植入24 h后，FSCPC中观察到比c-CPC中更高的c-CPC值。粉末XRD分析显示FSCPC比c-CPC更快地转化为HAP，这是从初始阶段开始的更快的凝固和更高的机械强度的原因。因此，我们得出结论，FSCPC可用于广泛的临床应用，即需要快速凝固的领域，如骨科、整形和重建以及口腔颌面外科。
The in vivo setting behaviour of fast-setting calcium phosphate cement (FSCPC) between femoral muscles of the rat was investigated to evaluate the possible value of FSCPC for medical and dental application. Conventional CPC (c-CPC) and FSCPC were implanted between femoral muscles, and various aspects of the setting behaviour such as setting time, mechanical strength and conversion ratio of cement into hydroxyapatite (HAP: Ca-10(PO4)(6)(OH)(2)) were measured by the Vicat needle method, diametral tensile strength (DTS) measurement, and quantitative powder X-ray diffraction (XRD) analysis, respectively. The setting time of FSCPC in vivo was 5-7 min, in contrast to 48 min for c-CPC. As a result of its fast setting, set specimens of FSCPC showed higher mechanical strength from the initial stage than c-GPC. Higher DTS values were observed in FSCPC than c-CPC implanted after 24 h. Powder XRD analysis revealed faster conversion of FSCPC than c-CPC into HAP, which was responsible both for the faster setting and higher mechanical strength from the initial stage. We concluded, therefore, that FSCPC may be used for a wide range of clinical applications, i.e. fields where fast setting is required such as orthopaedic, plastic and reconstructive, and oral and maxillofacial surgery.