Tomographic molecular imaging of x-ray-excitable nanoparticles
Tomographic molecular imaging of x-ray-excitable nanoparticles
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DOI：
10.1364/ol.35.003345
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发表时间：
2010-10-15
期刊：
影响因子：
3.6
通讯作者：
Xing, Lei
中科院分区：
文献类型：
--
作者：
Pratx, Guillem;Carpenter, Colin M.;Xing, Lei
X射线荧光计算机断层扫描（XLCT）被提出作为一种新的双重分子/解剖成像模式。XLCT基于X射线可激发纳米颗粒的选择性激发和光学检测。作为概念的证明，我们建立了一个原型XLCT系统和成像近红外发射Gd 2 O2 S：Eu荧光粉在各种幻影。在光扩散介质中成像表明，成像性能不受光散射的影响;此外，重建图像的线性响应表明XLCT能够定量成像。(C)2010年美国光学学会
X-ray luminescence computed tomography (XLCT) is proposed as a new dual molecular/anatomical imaging modality. XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles. As a proof of concept, we built a prototype XLCT system and imaged near-IR-emitting Gd2O2S:Eu phosphors in various phantoms. Imaging in an optically diffusive medium shows that imaging performance is not affected by optical scatter; furthermore, the linear response of the reconstructed images suggests that XLCT is capable of quantitative imaging. (C) 2010 Optical Society of America