NPY receptors and opioidergic system are involved in NPY-induced feeding in goldfish
NPY receptors and opioidergic system are involved in NPY-induced feeding in goldfish
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DOI：
10.1016/s0196-9781(00)00303-x
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发表时间：
2000-10-01
期刊：
影响因子：
3
通讯作者：
Alonso-Bedate, M
中科院分区：
文献类型：
--
作者：
de Pedro, N;López-Patiño, MA;Alonso-Bedate, M
本研究评价了腹膜内（i. p.）和脑室内施用选择性Y-1 [（Leu（31），Pro（34））-NPY]和Y-2[（Pro（13），Tyr（36））-NPY（13-36）]受体激动剂对饱足金鱼的食物摄取的影响。在注射后2小时，Y-1激动剂（1 mug）的中央给药显著增加了食物摄入量（FI），但Y-2激动剂没有增加。由（Leu（31），Pro（34））-NPY诱导的摄食增加与ICV注射神经肽Y后获得的摄食增加的幅度相似，并且两种摄食刺激都被NPY（27-36）（一种通用的NPY拮抗剂）逆转。腹腔注射激动剂既没有显著改变（Y，激动剂）也没有显著降低（Y-1激动剂）金鱼的摄食量。这些数据表明，它是Y-1-样（类似于Y-1和/或Y-5）受体，而不是Y-2，这是在金鱼的摄食行为的中枢调制参与。我们还研究了阿片肽可能的参与：介质的神经肽Y刺激行动对金鱼的食物摄取。ICV管理纳洛酮（10杯），一般阿片类药物拮抗剂，阻断了NPY诱导的金鱼摄食，表明阿片系统参与摄食调节NPY。(C)2000年由Elsevier Science Inc.出版
The present study evaluated the effects of both intraperitoneal (i.p.) and intracerebroventricular administration of selective Y-1 [(Leu(31), Pro(34))-NPY] and Y-2[(Pro(13), Tyr(36))-NPY (13-36)] receptor agonists on food intake in satiated goldfish. Food intake (FI) was significantly increased by central administration of the Y-1 agonist (1 mug), but not by the Y-2 agonist, at 2 h postinjection. The feeding increase induced by (Leu(31), Pro(34))-NPY was in a similar magnitude to that obtained after ICV injection of the neuropeptide Y, and both feeding stimulations were reversed by the NPY (27-36), a general NPY antagonist. The i.p. administration of the agonists either did not significantly modify (Y, agonist) or decreased (Y-1 agonist) food intake in goldfish. These data indicate that it is the Y-1-like (similar to Y-1 and/or Y-5) receptor, and not Y-2, that is involved in the central modulation of the feeding behavior in goldfish. We also investigated the possible involvement of opioid peptides as: mediators of the NPY stimulatory action on food intake in goldfish. The ICV administration of naloxone (10 mug), a general opioid antagonist, blocked the NPY-induced feeding in goldfish, suggesting that the opioidergic system is involved in feeding regulation by NPY. (C) 2000 Published by Elsevier Science Inc.