Preparation of calcium phosphate cement and polymethyl methacrylate for biological composite bone cements.
Preparation of calcium phosphate cement and polymethyl methacrylate for biological composite bone cements.
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DOI：
10.12659/msm.893845
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发表时间：
2015-04-23
期刊：
影响因子：
--
通讯作者：
Yu B
中科院分区：
文献类型：
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作者：
Yang J;Zhang K;Zhang S;Fan J;Guo X;Dong W;Wang S;Chen Y;Yu B
研究了磷酸钙骨水泥与聚甲基丙烯酸甲酯复合骨水泥以不同比例混合后的生物安全性、生物力学和组织相容性。CPC和PMMA以不同比例（3：1、2：1、1：1、1：2、1：5、1：10、1：15和1：20）混合。PMMA溶剂是一种通用溶剂，含有特定于给定样本的复合骨水泥溶解制剂，用于确定生物安全性、生物力学和组织相容性。CPC/PMMA组（33%）、CPC/PMMA组（50%）、CPC/PMMA组（67%）、CPC/PMMA组（75%）更符合复合骨水泥无细胞毒性要求。CPC/PMMA（67%）组和CPC/PMMA（75%）组的抗压强度为20 Mpa ~ 30 Mpa，CPC/PMMA（4.8%）组、CPC/PMMA（6.25%）组、CPC/PMMA（9.1%）组、CPC/PMMA（16.7%）组、CPC/PMMA（33%）组和CPC/PMMA（50%）组的抗压强度为40 Mpa ~ 70 Mpa。CPC组的固化时间较长（超过11 min），PMMA组的固化时间较短（小于2 min）。体重减轻率结果显示，CPC/PMMA组（4.8%、6.25%、9.1%、16.7%、33%）与PMMA对照组无显著差异（p>0.05）。随着CPC含量的降低，失重率逐渐降低。CPC/PMMA（50%）组、CPC/PMMA（67%）组和CPC/PMMA（75%）组为复合骨水泥提供了更大的可变性和选择性，以获得更好的应用。
We studied the biological safety, biomechanics, and tissue compatibility of calcium phosphate cement and Polymethyl Methacrylate composite bone cement mixed in different ratios. CPC and PMMA were mixed in different ratios (3: 1, 2: 1, 1: 1, 1: 2, 1: 5, 1: 10, 1: 15, and 1: 20). PMMA solvent is a general solvent containing a dissolved preparation of the composite bone cement specific to a given specimen to determine biological safety, biomechanics, and tissue compatibility. The CPC/PMMA (33%) group, CPC/PMMA (50%) group, CPC/PMMA (67%) group, and CPC/PMMA (75%) group were more in line with the composite bone cement without cytotoxicity requirements. The compressive strength of the CPC/PMMA (67%) group and CPC/PMMA (75%) group was 20Mpa–30Mpa, while that of the CPC/PMMA (4.8%) group, CPC/PMMA (6.25%) group, CPC/PMMA (9.1%) group, CPC/PMMA (16.7%) group, CPC/PMMA (33%) group, and CPC/PMMA (50%) group was 40Mpa–70Mpa. Curing time was longer in the CPC group (more than 11 min) and shorter in the PMMA group (less than 2 min). The results of weight loss rate showed that there were no significant differences between the CPC/PMMA group (4.8%, 6.25%, 9.1%, 16.7%, 33%) and PMMA control group (p>0.05). With the decrease of CPC content, the rate of weight loss gradually decreased. The CPC/PMMA (50%) group, CPC/PMMA (67%) group, and CPC/PMMA (75%) group provide greater variability and selectivity for the composite bone cement in obtaining better application.