Neural Aspects of Inhibition Following Emotional Primes in Depressed Adolescents.
Neural Aspects of Inhibition Following Emotional Primes in Depressed Adolescents.
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DOI：
10.1080/15374416.2014.982281
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Gotlib IH
中科院分区：
文献类型：
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作者：
Colich NL;Foland-Ross LC;Eggleston C;Singh MK;Gotlib IH
研究发现，被诊断患有重度抑郁症 (MDD) 的成年人的特点是选择性地关注负面材料，以及摆脱或抑制处理负面刺激的能力受损。额叶执行控制网络功能的改变被认为是这些认知功能缺陷的根源。然而，我们对抑郁青少年抑制困难的神经基础知之甚少。我们对 18 名被诊断患有 MDD 的青少年和 15 名年龄和性别匹配的健康对照 (CTL) 使用功能性磁共振成像，同时让他们执行修改后的情感进行/不进行任务，该任务旨在测量情绪干扰因素存在下的抑制控制。参与者会看到一张快乐或悲伤的脸，然后是一个可行或不可行的目标，他们可以做出或抑制运动反应。一组（MDD、CTL）按效价（快乐、悲伤）按条件（进行、不进行）进行方差分析表明，MDD 青少年在右侧背外侧前额叶皮层 (DLPFC) 和双侧枕叶皮层中，对悲伤而非快乐面孔后的不可行目标表现出减弱的 BOLD 反应。被诊断患有抑郁症的青少年在抑制试验中表现出前额叶控制区的异常募集，这表明与抑郁相关的情绪干扰抑制的神经基础受到破坏。鉴于 DLPFC 与目标相关信息的维护有关，悲伤的面孔很可能会不同程度地吸引 MDD 青少年的注意力，并干扰需要抑制的任务要求。关键词：青春期；沮丧;反应抑制；前额皮质；磁共振成像
Adults diagnosed with Major Depressive Disorder (MDD) have been found to be characterized by selective attention to negative material and by impairments in their ability to disengage from, or inhibit the processing of, negative stimuli. Altered functioning in the frontal executive control network has been posited to underlie these deficits in cognitive functioning. We know little, however, about the neural underpinnings of inhibitory difficulties in depressed adolescents. We used functional magnetic resonance imaging in 18 adolescents diagnosed with MDD and 15 age- and gender- matched healthy controls (CTLs) while they performed a modified affective go/no-go task that was designed to measure inhibitory control in the presence of an emotional distractor. Participants were presented with either a happy or a sad face, followed by a go or a no-go target to which they either made or inhibited a motor response. A group (MDD, CTL) by valence (happy, sad) by condition (go, no-go) analysis of variance indicated that MDD adolescents showed attenuated BOLD response in the right dorsolateral prefrontal cortex (DLPFC) and in the occipital cortex bilaterally, to no-go targets that followed a sad, but not a happy, face. Adolescents diagnosed with MDD showed anomalous recruitment of prefrontal control regions during inhibition trials, suggesting depression-associated disruption in neural underpinnings of the inhibition of emotional distractors. Given that the DLPFC is associated with the maintenance of goal-relevant information, it is likely that sad faces differentially capture attention in MDD adolescents and interfere with task demands requiring inhibition. Keywords: adolescence; depression; response inhibition; prefrontal cortex; fmri