Dendritic cells in cancer: the role revisited.
Dendritic cells in cancer: the role revisited.
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DOI：
10.1016/j.coi.2017.01.002
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发表时间：
2017-04
影响因子：
7
通讯作者：
Gabrilovich DI
中科院分区：
文献类型：
--
作者：
Veglia F;Gabrilovich DI
树突状细胞具有强大的抗原递呈能力，一直被认为是抗肿瘤免疫的关键因素。尽管促进抗肿瘤反应具有很高的潜力，但肿瘤相关dc的功能活性在很大程度上存在缺陷，可能有助于癌症的免疫抑制。近年来，肿瘤微环境中存在免疫抑制调节性dc。单核粒细胞来源的抑制细胞（M-MDSCs）可以通过分化为炎性dc （inf- dc）来促进肿瘤相关dc的形成，炎性dc似乎具有特定的表型，是抗肿瘤反应的关键组成部分。在这里，我们研究了if -DC和其他DC亚群在癌症免疫反应调节中的作用。这些新数据拓展了我们对dc在癌症中的作用的认识，并可能为免疫治疗提供新的靶点。
Dendritic cells (DCs) with their potent antigen presenting ability are long considered as critical factor in antitumor immunity. Despite high potential in promoting antitumor responses, tumor-associated DCs are largely defective in their functional activity and can contribute to immune suppression in cancer. In recent years existence of immune suppressive regulatory DCs in tumor microenvironment was described. Monocytic myeloid derived suppressor cells (M-MDSCs) can contribute to the pool of tumor associated DCs by differentiating to inflammatory DCs (inf-DCs), which appear to have specific phenotype and is critical component of antitumor response. Here we examine the role of inf-DCs along with other DC subsets in the regulation of immune responses in cancer. These novel data expand our view on the role of DCs in cancer and may provide new targets for immunotherapy.