Nanomedicine delivers promising treatments for rheumatoid arthritis.
Nanomedicine delivers promising treatments for rheumatoid arthritis.
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DOI：
10.2217/nnm.15.45
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Cui Z
中科院分区：
文献类型：
--
作者：
Prasad LK;O'Mary H;Cui Z
对慢性炎症性疾病（如风湿性关节炎）病理生理学的进一步了解表明，病变组织和组织内巨噬细胞和其他过表达分子的增加可以用来增强纳米药物的递送。纳米药物可以通过增强的渗透性和滞留现象被动地积累到慢性炎症组织中，或者与配体表面偶联，主动结合慢性炎症组织内细胞过度表达的受体，从而提高疗效，减少全身副作用。本文综述了近十年来利用纳米药物治疗类风湿关节炎的研究进展，并总结了利用纳米药物治疗这一常见病和慢性疾病的一些主要发现和前景。
An increased understanding in the pathophysiology of chronic inflammatory diseases, such as rheumatoid arthritis, reveals that the diseased tissue and the increased presence of macrophages and other overexpressed molecules within the tissue can be exploited to enhance the delivery of nanomedicine. Nanomedicine can passively accumulate into chronic inflammatory tissues via the enhanced permeability and retention phenomenon, or be surface conjugated with a ligand to actively bind to receptors overexpressed by cells within chronic inflammatory tissues, leading to increased efficacy and reduced systemic side-effects. This review highlights the research conducted over the past decade on using nanomedicine for potential treatment of rheumatoid arthritis and summarizes some of the major findings and promising opportunities on using nanomedicine to treat this prevalent and chronic disease.