Uptake, elimination, and biotransformation of aqueous and dietary DDT in marine fish
Uptake, elimination, and biotransformation of aqueous and dietary DDT in marine fish
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DOI：
10.1897/07-608.1
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发表时间：
2008-10-01
影响因子：
4.1
通讯作者：
Wang, Wen-Xiong
中科院分区：
文献类型：
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作者：
Kwong, Raymond W. M.;Yu, Peter K. N.;Wang, Wen-Xiong
为了了解对，对'-二氯二苯基三氯乙烷 (DDT) 及其代谢物对，对'-二氯二苯基二氯乙烷 (DDE) 和对,对'-二氯二苯基二氯乙烷 (DDD) 在鱼类中的生物动力学和潜在风险，我们将黑鲷 (Acanthopagrus schlegeli) 暴露于 水和膳食中的滴滴涕，然后在受控实验室条件下评估滴滴涕的生物累积、分布、生物转化和消除。两种接触途径的鱼都迅速积累了滴滴涕，特别是鳃和内脏。水或食物摄入后滴滴涕的消除很慢，滴滴涕的生物转运在暴露期间很显着，但在净化期间可以忽略不计。饮食暴露后的生物转化过程更加显着。在净化过程中，DDE是鲷鱼尸体中的主要生物转化产物，而DDD是鳃和内脏中的主要产物。然而，DDD 的消除率明显高于 DDE，因此鱼体内保留了更多的 DDE。观察到鱼类消除和生物转化过程的种内变异。我们证明，接触途径显着影响滴滴涕在鱼类中的归宿和生物动力学。动态模型的应用为量化DDT在鱼类中的消除和生物转化提供了工具。本研究深入了解了滴滴涕在鱼类中的生物累积和生物转化途径，可能具有重要的生态毒理学意义。
To understand the biokinetics and potential risks of p,p'-dichlorodiphenyltrichloroethane (DDT) and its metabolites, p,p'-dichlorodiphenyldichloroethylene (DDE) and p,p'-dichlorodiphenyldichloroethane (DDD), in fish, we exposed the black sea breams (Acanthopagrus schlegeli) to aqueous and dietary DDTs and then evaluated the bioaccumulation, distribution, biotransformation, and elimination of DDTs under controlled laboratory conditions. The fish rapidly accumulated DDTs from both routes of exposure, particularly the gills and viscera. Elimination of DDTs following aqueous or dietary uptake was slow, and biotranslocation of DDTs was significant during the exposure period but negligible during the depuration period. The biotransformation process was more significant following dietary exposure. During depuration, DDE was the major biotransformed product in the sea breams' carcasses while DDD was the major product in the gills and viscera. However, DDD had a significantly higher elimination rate than DDE and, subsequently, the fish retained more DDE in the body. Intraspecies variability in the elimination and biotransformation processes in fish was observed. We demonstrated that the route of exposure significantly affected the fate and biokinetics of DDTs in fish. The application of a dynamic model provided a tool for quantifying the elimination and biotransformation of DDT in fish. The present study provided insights into the bioaccumulation and biotransformation pathways of DDT in fish that could have important ecotoxicological implications.