A Higher Incidence of Intermittent Hypoxemic Episodes Is Associated with Severe Retinopathy of Prematurity
A Higher Incidence of Intermittent Hypoxemic Episodes Is Associated with Severe Retinopathy of Prematurity
复制标题
DOI：
10.1016/j.jpeds.2010.01.046
复制
发表时间：
2010-07-01
影响因子：
5.1
通讯作者：
Martin, Richard J.
中科院分区：
文献类型：
--
作者：
Di Fiore, Juliann M.;Bloom, Jeffrey N.;Martin, Richard J.
目的早产儿视网膜病变（Retinopathy of prematurity， ROP）是一种早产儿视网膜血管增殖性疾病，与氧合水平等多种因素有关。我们探讨了早产儿常见的间歇性低氧血症事件是否与ROP的发展有关。研究设计对79名早产儿（胎龄，24至27-6/7周）在生命的前8周内的氧去饱和事件进行量化。婴儿被分为需要激光治疗ROP和不严重ROP或没有ROP。采用线性混合模型研究间歇性缺氧发生率与激光治疗ROP之间的关系，控制胎龄、性别、种族、多胎和初始疾病严重程度。结果所有婴儿低氧血症事件随出生年龄增加(P
Objective Retinopathy of prematurity (ROP), a vasoproliferative disorder of the retina in preterm infants, is associated with multiple factors, including oxygenation level. We explored whether the common intermittent hypoxemic events in preterm infants are associated with the development of ROP.Study design Oxygen desaturation events were quantified in 79 preterm infants (gestational age, 24 to 27-6/7 weeks) during the first 8 weeks of life. Infants were classified as requiring laser treatment for ROP versus having less severe or no ROP. A linear mixed model was used to study the association between the incidence of intermittent hypoxia and laser treatment of ROP, controlling for gestational age, sex, race, multiple births, and initial severity of illness.Results For all infants, hypoxemic events increased with postnatal age (P