Potassium chloride supplementation diminishes platelet reactivity in humans
Potassium chloride supplementation diminishes platelet reactivity in humans
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DOI：
10.1161/01.hyp.0000147660.58694.6f
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发表时间：
2004-12-01
期刊：
影响因子：
8.3
通讯作者：
Aviv, A
中科院分区：
文献类型：
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作者：
Kimura, M;Lu, XB;Aviv, A
闭塞性卒中的患病率与钾摄入量呈负相关。我们探讨了高钾摄入减弱血小板反应性的假设，如ADP诱导的血小板聚集。我们研究了健康男性（n = 31）和女性（n = 42），黑人（n = 33）和白人（n = 40）。在该队列中，我们补充了17名男性和21名女性的习惯摄入量，每天60 mmol KCl/70 kg体重，持续3天，并维持14名男性和21名女性的习惯摄入量。然后，我们比较了ADP浓度的变化，导致50%的最大初始速率（EC 50）的血小板聚集在补钾与对照组。补充钾可减弱血小板反应性，表现为血小板聚集的EC 50增加（P = 0.0005），这主要归因于白人的EC 50增加（P = 0.0004）。在基础条件下和补钾后，黑人的尿钾排泄量显著低于白人。我们的结论是补钾降低了血小板的反应性，这一现象提供了血小板生物学和闭塞性卒中之间的联系。
The prevalence of occlusive stroke is inversely correlated with potassium intake. We explored the hypothesis that a high potassium intake attenuates platelet reactivity, as expressed in ADP-evoked platelet aggregation. We studied healthy men (n = 31) and women ( n = 42), blacks ( n = 33) and whites ( n = 40). In this cohort, we supplemented the habitual intake of 17 men and 21 women with 60 mmol KCl/70 kg body weight per day for 3 days and maintained 14 men and 21 women on their habitual intake. We then compared the change in ADP concentration causing 50% of the maximal initial rate (EC50) of platelet aggregation in the potassium-supplemented versus control groups. Potassium supplementation attenuated platelet reactivity, expressed by an increase in EC50 of platelet aggregation ( P = 0.0005), which was primarily attributable to an increase in EC50 in whites ( P = 0.0004). Urinary potassium excretion was significantly lower in blacks than in whites under basal conditions and after potassium supplementation. We conclude that potassium supplementation diminishes platelet reactivity, a phenomenon that provides a link between platelet biology and occlusive stroke.