Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss
Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss
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DOI：
10.1111/j.1600-0897.2010.00863.x
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发表时间：
2010-12-01
影响因子：
3.6
通讯作者：
Di Simone, Nicoletta
中科院分区：
文献类型：
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作者：
Ticconi, Carlo;Rotondi, Federica;Di Simone, Nicoletta
ProblemTo调查的可能性，抗核抗体（ANA）参与复发性妊娠loss（RPL）。MethodsCase-control study进行了294名妇女（194例和100对照）在两所大学医院。的存在，血清滴度和ANA的间接免疫荧光（IIF）模式，确定在妇女与RPL和对照women.ResultsAntinuclear antibodies在滴度>= 1：80检测97（50%）妇女与RPL和16（16%）对照妇女。仅在RPL妇女中检测到ANA滴度升高（>= 1：180），而所有对照妇女的ANA滴度均不大于1：80。RPL和对照组妇女的IIF模式无差异。ANA阳性无差异，可以检测到根据类型（原发性或继发性）或数量（>2与>= 3）的losss.ConclusionsANA可能有一定的价值，在确定妇女RPL与潜在的，虽然还没有完全定义，免疫异常。
ProblemTo investigate the possibility that antinuclear antibodies (ANA) are involved in recurrent pregnancy loss (RPL).MethodsCase-control study carried out on 294 women (194 cases and 100 controls) in two University hospitals. The presence, the serum titers and the indirect immunofluorescence (IIF) patterns of ANA were determined in women with RPL and in control women.ResultsAntinuclear antibodies at titers >= 1:80 were detected in 97 (50%) women with RPL and in 16 (16%) control women. Elevated ANA titers (>= 1:180) were detected only in RPL women, whereas all control women had ANA titers no greater than 1:80. No differences could be detected in the IIF patterns between RPL and control women. No differences in ANA positivity could be detected according to the type (primary or secondary) or number (>2 versus >= 3) of losses.ConclusionsANA could be of some value in identifying women with RPL with potential, although still not fully defined, immune abnormalities.