Gap junctions in vascular smooth muscle.
Gap junctions in vascular smooth muscle.
复制标题
血管平滑肌中的间隙连接。
DOI：
10.1046/j.1365-201x.1998.00439.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Brink,PR
中科院分区：
文献类型：
--
作者：
Brink,PR
间隙连接通道是唯一一类跨越两个紧密贴壁的质膜的通道。有超过一打已鉴定的亚基蛋白或连接蛋白。三种通用类型的间隙连接通道是可能的。它们是同型、异型和异聚体类型，每种类型都具有不同的连接蛋白分布。在血管平滑肌中发现的主要连接蛋白是连接蛋白43。在血管平滑肌中也发现了连接蛋白40。连接蛋白43的生物合成、运输和降解只是最近才被研究，但数据揭示了一些有趣的特征，例如半衰期短，仅为1.5-3.5小时。 connexin 43的门控特性揭示了导致大多数差距连接通道延长关闭的模式转换行为。该通道还显示出弱的电压依赖性，并且选择性差。这些特征表明，细胞间偶联的动态调节最好是通过生物合成、运输、降解途径和模式转换门控下调通道活性来减少细胞间偶联，而不是增强细胞间偶联。
Gap junction channels are the only class of channels which span two closely apposed plasma membranes. There are over a dozen identified subunit proteins or connexins. Three generic types of gap junction channels are possible. They are the homotypic, heterotypic and heteromeric types, each of which has a distinct connexin distribution. The major connexin found in vascular smooth muscle is connexin43. Connexin40 has also been found in vascular smooth muscle. The biosynthesis, trafficking and degradation of connexin43 has only recently been studied but the data reveal some interesting features such as a short half‐life of only 1.5–3.5 h. The gating characteristics of connexin43 reveal mode shifting behaviours which result in prolonged closure of the majority of the gap junction channels. The channel also displays weak voltage dependence and is poorly selective. These features suggest that dynamical regulation of cell‐to‐cell coupling is best designed to reduce cell‐to‐cell coupling, rather than enhance it, by down regulation of channel activity through the biosynthesis, trafficking, degradation pathways and gating via mode shifting.