Differential expression of oxygen sensitivity in voltage-dependent K channels in inbred strains of mice.
Differential expression of oxygen sensitivity in voltage-dependent K channels in inbred strains of mice.
复制标题
近交系小鼠电压依赖性 K 通道氧敏感性的差异表达。
DOI：
10.1007/0-387-31311-7_32
复制
发表时间：
2006
影响因子：
--
通讯作者：
Shirahata,Machiko
中科院分区：
文献类型：
--
作者：
Otsubo,Toshiki;Yamaguchi,Shigeki;Okumura,Mariko;Shirahata,Machiko
摘要化学感觉球体细胞电压依赖性钾通道(Kv通道)对氧的敏感性参与了颈动脉小体的低氧化学转导过程。随着时间的推移，对双胞胎和个体的人类研究表明，颈动脉小体的缺氧敏感性是由基因控制的(Collins等人，1978；Kawakami等人，1982；Nishimura等人，1991；Thomas等人，1993)。这一概念在使用近交系小鼠(Tankersley等人，1994；Campene等人，2004)和大鼠(Weil等人，1998)的研究中得到了进一步证实，这些近交系小鼠在一个品系中的遗传几乎相同。在这些研究中，对低氧的呼吸或心血管反应在几个菌株之间有所不同，但在同一菌株内是相似的。因此，一些由于遗传差异而在个体中差异表达的蛋白质可能会引起不同的颈动脉小体反应。我们推测，氧敏Kv通道的差异表达是造成DBA/2J和A/J小鼠品系缺氧敏感性差异的原因之一。
AbstractOxygen sensitivity of voltage-dependent K channels (Kv channels) in chemosensory glomus cells is responsible for hypoxic chemotransduction processes in the carotid body. Human studies in twins and in individuals over time suggest that hypoxic sensitivity of the carotid body is genetically controlled (Collins et al., 1978; Kawakami et al., 1982; Nishimura et al., 1991; Thomas et al., 1993). The concept is further confirmed in the studies using inbred strains of mice (Tankersley et al., 1994; Campen et al., 2004) and rats (Weil et al., 1998) which are genetically almost identical within a strain. In these studies, respiratory or cardiovascular responses to hypoxia vary among several strains, but are similar within a strain. Thus, some proteins which are differentially expressed in individuals due to genetic differences likely cause variable carotid body responses. We have hypothesized that differential expression of oxygensensitive Kv channels contributes to the differences in hypoxic sensitivity of DBA/2J and A/J strains of mice.