miRNA regulation of white and brown adipose tissue differentiation and function.
miRNA regulation of white and brown adipose tissue differentiation and function.
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DOI：
10.1016/j.bbalip.2016.02.010
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Fernández-Hernando C
中科院分区：
文献类型：
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作者：
Price NL;Fernández-Hernando C
肥胖和代谢紊乱是所有发达国家的主要健康问题，当前医学研究的一个主要重点是提高我们对代谢性疾病的认识和治疗。最近吸引了人们极大兴趣的一个研究途径是了解miRNAs在代谢性疾病发展中的作用。在肥胖和胰岛素抵抗的情况下，miRNAs在许多不同的组织中被证明是失调的，并且已经被证明是许多关键代谢功能的重要调节因子，包括胰腺的胰岛素分泌，肝脏的脂肪和葡萄糖代谢，以及下丘脑的营养信号。在这篇综述中，我们将重点介绍miRNAs在调节白色和棕色脂肪组织分化和功能中的重要作用，以及这对维持代谢功能和治疗代谢性疾病的潜在重要性。
Obesity and metabolic disorders are a major health concern in all developed countries and a primary focus of current medical research is to improve our understanding treatment of metabolic diseases. One avenue of research that has attracted a great deal of recent interest focuses upon understanding the role of miRNAs in the development of metabolic diseases. miRNAs have been shown to be dysregulated in a number of different tissues under conditions of obesity and insulin resistance, and have been demonstrated to be important regulators of a number of critical metabolic functions, including insulin secretion in the pancreas, lipid and glucose metabolism in the liver, and nutrient signaling in the hypothalymus. In this review we will focus on the important role of miRNAs in regulating the differentiation and function of white and brown adipose tissue and the potential importance of this for maintaining metabolic function and treating metabolic diseases.