Error-related brain activity and internalizing disorder symptom dimensions in depression and anxiety
Error-related brain activity and internalizing disorder symptom dimensions in depression and anxiety
复制标题
DOI：
10.1002/da.22648
复制
发表时间：
2017-11-01
影响因子：
7.4
通讯作者：
Phan, K. Luan
中科院分区：
文献类型：
--
作者：
Gorka, Stephanie M.;Burkhouse, Katie L.;Phan, K. Luan
背景研究表明，通过错误相关消极性（ERN）测量的对错误的神经反应增强对于内化精神病理学（IP）和以过度担忧和忧虑为特征的症状群来说是相对独特的。然而，之前没有研究在异质的、具有临床代表性的患者群体中测试 ERN 和 IP 症状维度之间的关联。当前的研究旨在解决文献中的这一空白，并阐明 ERN 在寻求成人 IP 治疗的患者样本中的作用。 方法 85 名参与者完成了一项经过充分验证的侧翼任务，已知该任务可以有力地引发 ERN 和评估一系列 IP 症状的问卷调查。所有参与者都至少有一种 IP 诊断，超过 75% 的人有同时发生的 IP。对问卷数据进行主成分分析 (PCA)，表明表征 IP 样本的两个不同因素：情感困扰/痛苦和基于恐惧的焦虑。结果分析表明，在该样本中，增强的 ERN（而非 CRN）与更大的基于恐惧的焦虑症状相关，但与痛苦/痛苦症状无关。结论 总之，这些发现表明，增强的 ERN 可能不是担心/忧虑所特有的，可能会扩展到 IP 恐惧维度。研究结果也与更广泛的文献相一致，表明基于恐惧的精神病理学的特点是对威胁的过度反应，这种客观的心理生理反应倾向可以区分恐惧症和痛苦。
BackgroundResearch suggests that enhanced neural reactivity to errors, measured via the error-related negativity (ERN), is relatively unique to internalizing psychopathologies (IPs) and symptom clusters characterized by excessive worry and apprehension. However, no prior study has tested the association between the ERN and IP symptom dimensions in a heterogeneous, clinically representative patient population. The current study was designed to address this gap in the literature and clarify the role of the ERN in an adult IP treatment-seeking patient sample.MethodEighty-five participants completed a well-validated flanker task known to robustly elicit the ERN and a battery of questionnaires assessing a range of IP symptoms. All participants had at least one IP diagnosis and over 75% had co-occurring IPs. A principal components analysis (PCA) was performed on the questionnaire data indicating two distinct factors that characterized the IP sample: affective distress/misery and fear-based anxiety.ResultsAnalyses indicated that within this sample, an enhanced ERN, but not CRN, was associated with greater fear-based anxiety symptoms but had no relation with distress/misery symptoms.ConclusionsTogether, these findings indicate that an enhanced ERN may not be specific to worry/apprehension and may extend to the IP fear dimension. The results also converge with a broader literature suggesting that fear-based psychopathology is characterized by an exaggerated reactivity to threat and this objective, psychophysiological response tendency may distinguish fear disorders from distress.