OCTA-Based Identification of Different Vascular Patterns in Stargardt Disease
OCTA-Based Identification of Different Vascular Patterns in Stargardt Disease
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DOI：
10.1167/tvst.8.6.26
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发表时间：
2019-11-01
影响因子：
3
通讯作者：
Parodi, Maurizio Battaglia
中科院分区：
文献类型：
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作者：
Arrigo, Alessandro;Romano, Francesco;Parodi, Maurizio Battaglia
目的：本研究的目的是分析定量光学相干断层扫描（OCT）和OCT血管造影（OCTA）参数，以确定临床相关的截止值能够检测临床不同的Stargardt病（STGD）subgroup.Methods：连续性STGD患者进行招募，并进行完整的眼科检查，包括多模式成像。从结构OCT和OCTA图像中提取几个定量参数，并进行统计分析。进行事后分析以确定能够区分两个临床上不同的STGD亚组的定量截止值。主要观察指标为视网膜总厚度、黄斑中心厚度（CMT）、视网膜层厚度、视网膜和脉络膜高反射灶（HF）数量、血管密度（VD）、血管迂曲度（VT）、血管离散度（Vdisp）以及黄斑和视神经头丛的血管稀疏度（VR）。总体而言，54名STGD患者（18名男性）的54只眼睛和54名年龄和性别匹配的健康对照的54只眼睛被纳入分析。STGD组各项定量指标均显著低于对照组（P
Purpose: The aim of the present study was to analyze quantitative optical coherence tomography (OCT) and OCT angiography (OCTA) parameters to identify clinically relevant cutoff values able to detect clinically different Stargardt's disease (STGD) subgroups.Methods: Consecutive STGD patients were recruited and underwent complete ophthalmologic examination, including multimodal imaging. Several quantitative parameters were extracted both from structural OCT and OCTA images and were statistically analyzed. A post hoc analysis was performed to identify a quantitative cutoff able to distinguish two clinically different STGD subgroups. Main outcome measures were total retinal thickness, central macular thickness (CMT), retinal layers thickness, retinal and choroidal hyperreflective foci (HF) number, vessel density (VD), vessel tortuosity (VT), vessel dispersion (Vdisp), and vessel rarefaction (VR) of macular and optic nerve head plexa.Results: Overall, 54 eyes of 54 STGD patients (18 males) and 54 eyes of 54 healthy age- and sex-matched controls were included in the analysis. All quantitative parameters resulted significantly worse in STGD than controls (P