Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat
Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat
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DOI：
10.1111/j.1469-7793.2001.0171j.x
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发表时间：
2001-02-15
影响因子：
5.5
通讯作者：
Poole, S
中科院分区：
文献类型：
--
作者：
Cartmell, T;Luheshi, GN;Poole, S
1.白细胞介素（IL）-1是宿主对炎症和损伤（包括发热）的防御反应的介质，但其合成位点和作用尚未完全阐明。IL-1的作用可被IL-1受体拮抗剂（IL-1 ra）拮抗。本研究验证了IL-1和IL-1 ra在大鼠外周炎症部位局部产生的假设，以及内源性IL-1 ra的作用是限制炎症引起的发热.将脂多糖（LPS; 100 μ g kg（-1））注射到皮下气囊（I. P.）大鼠的体温显著升高。在注射LPS后1至8小时（当实验终止时），几乎所有（类似于85%）注射的LPS都从囊袋中回收，但LPS检测不到（
1. Interleukin (IL)-1 is a mediator of host defence responses to inflammation and injury, including fever, but its sites of synthesis: and action have not been fully elucidated. The actions of IL-1 are antagonised by IL-1 receptor antagonist (IL-1ra). The present study tested the hypothesis that IL-1 and IL-1ra are produced locally at sites of peripheral inflammation in rats, and that endogenous IL-1ra acts to limit the fever resulting from the inflammation.2. Injection of lipopolysaccharide (LPS; 100 mug kg(-1)) into a subcutaneous air pouch (I.PO.) of rats induced a significant increase in body temperature. Virtually all (similar to 85%) of the injected LPS was recovered from the pouch between 1 and 8 h (when the experiment was terminated) after injection of LPS, but LPS was undetectable (